Exemestane has a limited aqueous solubility that leads to a very high variability in absorption when administrated orally. It is crucial to develop strategies to increase the solubility and bioavailability of this drug. To overcome these issues, the aim of the present work was the development of magnetic silica mesoporous nanoparticles (IOMSNs) to carry and release exemestane. Furthermore, these nanoparticles could be also used as Magnetic Resonance Imaging (MRI) contrast agents for treatment monitorization and tumor detection. MRI analysis showed that IOMSNs present a concentration dependent contrast effect, revealing their potential for MRI applications. Also, IOMSNs present a very good polydispersity (0.224) and nanometric range size (137.2 nm). It was confirmed that the nucleus is composed by magnetite and the silica coating presents tubes with MCM-41-like hexagonal structure. Both iron oxide nanoparticles and iron oxide mesoporous silica nanoparticles were not toxic in cell culture for 24 h. Exemestane was successful released for 72 h following a typical sustained release pattern, achieving a very high loading capacity (37.7%) and in vitro release of 98.8%. Taking into account the results it is possible to conclude that IOMSNs have a high potential to be used as theranostic for intravenous breast cancer treatment with exemestane.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpharm.2022.121711 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of Mesoporous Silica Nanoparticles as Carriers of Triarylmethyl Radical Spin Probes for EPR Oximetry.
J Phys Chem B
January 2025
Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506, United States.
measurement and mapping of oxygen levels within the tissues are crucial in understanding the physiopathological processes of numerous diseases, such as cancer, diabetes, or peripheral vascular diseases. Electron paramagnetic resonance (EPR) associated with biocompatible exogenous spin probes, such as Ox071 triarylmethyl (TAM) radical, is becoming the new gold standard for oxygen mapping in preclinical settings. However, these probes do not show tissue selectivity when injected systemically, and they are not cell permeable, reporting oxygen from the extracellular compartment only.
View Article and Find Full Text PDFZSM-5 Zeolite Synthesis from Coal Fly Ash Synthesised Silica: Sole Silica & Alumina Source.
ChemistryOpen
January 2025
Department of Chemistry, University of Botswana, Botswana Private bag UB, Gaborone, 00704, Botswana.
This study explores the synthesis of ZSM-5 zeolite using high-purity mesoporous silica exclusively derived from coal fly ash (CFA), eliminating the need for additional silica or alumina sources. Traditional ZSM-5 synthesis relies on costly and environmentally harmful pure chemicals, whereas this approach utilizes CFA, an industrial byproduct, addressing both cost and sustainability concerns. The synthesized ZSM-5 zeolite demonstrates exceptional purity, with a surface area of 455.
View Article and Find Full Text PDFMetal halide perovskites have unique luminescent properties that make them an attractive alternative for high quality light-emitting devices. However, the poor stability of perovskites with many defects and the long cycle time for the preparation of perovskite nanocomposites have hindered their production and application. Here, we prepared the perovskite mesostructures by embedding MAPbBr nanocrystals in the mesopores on the surface of silica nanospheres and mixing the nanospheres with silver nanowires and poly(methyl methacrylate) (PMMA), and further explored their optical properties.
View Article and Find Full Text PDFHollow mesoporous silica nanoparticles for drug formulation and delivery: Opportunities for cancer therapy.
Colloids Surf B Biointerfaces
January 2025
Shaanxi Key Laboratory of Catalysis, School of Chemistry and Environment Science, Shaanxi University of Technology, No.1 East 1st Ring Road, Hanzhong, Shaanxi 723001, PR China.
The advantages of large surface area, high volume ratio, good biocompatibility, and controllable surface functionalization make hollow mesoporous silica nanoparticles (HMSNs) an ideal drug carrier. HMSNs can achieve high efficiency, targeting, and controlled release by adjusting the microstructure and surface modification of its particles, which makes it broad application prospects in the field of medical therapy, especially in cancer therapy. Numerous studies have shown that preparation method, shape, particle size, hollow inner diameter, aperture and wall thickness of the HMSNs, the characteristics of the drugs, the interaction between the drugs and the carriers, and the external environment all closely affect the drug delivery, release, and efficacy.
View Article and Find Full Text PDFMicrofluidic-assisted sol-gel preparation of monodisperse mesoporous silica microspheres with controlled size, surface morphology, porosity and stiffness.
Nanoscale
January 2025
National Engineering Research Center for Colloidal Materials, School of Chemistry & Chemical Engineering, Shandong University, Jinan 250100, P. R. China.
The controllable synthesis of monodisperse mesoporous silica microspheres with unique physicochemical properties is becoming increasingly important for a variety of applications such as catalysts, chromatography, drug delivery and sensors. Here, we report a facile microfluidic-assisted sol-gel method for the preparation of silica microspheres with precisely controlled properties such as the size of the microspheres, the surface morphology, porosity and stiffness. All these properties can be manipulated by changing specific synthesis parameters, such as changing the microfluidic channels to tune the size of the microdroplets (tens to hundreds of microns), changing the contents of the precursor solution to manipulate the surface morphology (wrinkled to smooth surface) and changing the gelation/annealing conditions to tune the porosity (surface area up to 1021 m g) and stiffness of the microspheres (elastic modulus tunable from 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!