For many, Robert Rössle is one of the most important pathologists of the first half of the 20th century. His research in the fields of inflammation, constitution, growth and age, and immunity gave him the status of a pioneer. Because he was not a nominal member of the Nazi Party (NSDAP), Rössle did not have to undergo denazification proceedings and was able to continue his academic career seamlessly after 1945. Only recently, the question of Rössle's actual role in the Third Reich has been raised - in connection with a possible renaming of the Robert-Rössle-Straße in Berlin. Our paper takes this issue as an opportunity to critically examine Rössle's involvement in National Socialism. For this study, all available literature and extensive primary material on Rössle from various archives was reviewed and evaluated with regard to the question posed. The investigations show that Rössle held a number of offices in the administrative apparatus of the Nazi state even though not being a party member. They gave him access to high-ranking representatives and most likely also knowledge about medical crimes. Rössle researched and published on hereditary biology and racial hygiene issues, thus supporting the ideology of the Nazi State. Robert Rössle must be regarded as an early proponent of racial hygiene, political collaborator and profiteer of the Third Reich. However, it remains unclear whether he was directly involved in human experiments. There is no evidence that he critically distanced himself from his role in the Third Reich after 1945.
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http://dx.doi.org/10.1016/j.prp.2022.153842 | DOI Listing |
J Neuroinflammation
January 2025
Viral Immunology Section, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Building 10, Room 5C103, 10 Center Drive, Bethesda, MD, 20892-1400, USA.
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) and is a leading non-traumatic cause of disability in young adults. The 18 kDa Translocator Protein (TSPO) is a mitochondrial protein and positron emission tomography (PET)-imaging target that is highly expressed in MS brain lesions. It is used as an inflammatory biomarker and has been proposed as a therapeutic target.
View Article and Find Full Text PDFJ Neuroimaging
January 2025
Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Background And Purpose: MRI is crucial for multiple sclerosis (MS), but the relative value of portable ultra-low field MRI (pULF-MRI), a technology that holds promise for extending access to MRI, is unknown. We assessed white matter lesion (WML) detection on pULF-MRI compared to high-field MRI (HF-MRI), focusing on blinded assessments, assessor self-training, and multiplanar acquisitions.
Methods: Fifty-five adults with MS underwent pULF-MRI following their HF-MRI.
Am J Med Genet A
November 2024
Department of Agricultural Markets, University of Hohenheim, Stuttgart, Germany.
Peter Emil Becker was a German neurologist who is remembered for his studies of muscular dystrophies. Becker muscular dystrophy and Becker myotonia are named after him. His biography appeared in the American Journal of Medical Genetics in 1985.
View Article and Find Full Text PDFJ Am Podiatr Med Assoc
November 2024
†Department of Physical Therapy, Thomas Jefferson University, Philadelphia, PA.
Background: Identification of a specific causal mechanism for medial tibial stress syndrome has been elusive, although there is a consensus that it may be caused by traction on the tibial periosteum elicited by soft tissues. The crural fascia (CF) attaches directly to the tibia throughout the length of the leg, encircling it in a grossly cylindrical fashion, and the leg may thus be viewed as a type of fluid-filled cylinder, subject to both longitudinal and hoop stresses. Prior researchers have not considered the possibility that strain on the medial tibia could be produced by the CF during gait and passive stretching, secondary to fluid pressure increases in the fascial compartments of the leg.
View Article and Find Full Text PDFJMIR Form Res
November 2024
Clinic for Psychiatry, Psychosomatics and Psychotherapy, University Hospital, Goethe University Frankfurt, Frankfurt am Main, Germany.
Background: Online interventions, such as the iFightDepression (iFD) tool, are increasingly recognized as effective alternatives to traditional face-to-face psychotherapy or pharmacotherapy for treating depression. However, particularly when used outside of study settings, low adherence rates and the resulting diminished benefits of the intervention can limit their effectiveness. Understanding the factors that predict adherence would allow for early, tailored interventions for individuals at risk of nonadherence, thereby enhancing user engagement and optimizing therapeutic outcomes.
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