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Limited use of opioid prescribing guidelines in Dutch emergency departments: results of a nationwide survey.
Int J Emerg Med
December 2024
Nijmegen Institute for Science Practitioners in Addiction (NISPA), Nijmegen, The Netherlands.
Background: In recent years, the Netherlands has experienced a notable increase in opioid prescriptions and associated fatalities. Emergency department (ED) patients exhibit relatively high rates of opioid use (15%) and misuse (23% of patients who present to the ED and use prescription opioids test positive for misuse). To mitigate opioid-related harm, the American College of Emergency Physicians (ACEP) advocates for the use of non-opioid analgesics and minimal opioid prescriptions.
View Article and Find Full Text PDFPostoperative Opioid Consumption After Discharge: An Update From the Michigan Surgical Quality Collaborative Registry.
Ann Surg Open
December 2024
Department of Anesthesiology, University of Michigan, Ann Arbor, MI.
Objective: To evaluate opioid consumption for 21 procedures over 4 years from the Michigan Surgical Quality Collaborative (MSQC) registry and update post-discharge prescribing guidelines.
Background: Opioids remain a common treatment for postoperative pain of moderate-to-severe intensity not adequately addressed by nonopioid analgesics, but excessive prescribing correlates with increased usage. This analysis provides updates and compares patient-reported consumption in response to new guidelines.
Knowledge, Awareness, and Attitudes Regarding Self-Medication With Non-opioid Analgesics Among Students in Hafar Al-Batin, Saudi Arabia: A Cross-Sectional Study.
Cureus
November 2024
College of Medicine, Sulaiman Al Rajhi University, Al Bukayriyah, SAU.
Introduction: Self-medication (SM) with non-opioid analgesics (NOAs) has become increasingly prevalent, with individuals using over-the-counter medications to manage pain and other symptoms without professional guidance. While NOAs are generally considered safe when used appropriately, misuse or overuse can lead to adverse effects, including gastrointestinal issues, liver damage, and renal problems.
Aim: This study aimed to evaluate the knowledge, awareness, and attitudes regarding NOAs and their SM practices, including how these factors vary by demographic characteristics.
The effects of chronic neuropathic pain states on the discriminative stimulus effect of fentanyl and other MOR agonists.
bioRxiv
November 2024
Department of Pharmacology, University of Michigan, Ann Arbor Michigan, 48109.
Pleasant subjective effects of drugs (e.g., euphoria) have been demonstrated to contribute to their abuse potential.
View Article and Find Full Text PDFAnti-tumor activity of butorphanol in colorectal cancer via targeting SIGMAR1.
Discov Oncol
November 2024
Department of Surgical Anesthesiology, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, No. 201-209, Hubinnan Road, Siming District, Xiamen, 361000, Fujian, China.
Colorectal cancer (CRC) stands for a prevailing gastrointestinal neoplasm, concomitant with considerable occurrence and lethality rate. Butorphanol, a synthetic opioid analgesic medication targeting the opiate receptor, has been recently reckoned to harbor anti-oncogenic properties. This study proposes to delineate the impacts of butorphanol on CRC and the interrelated response mechanism.
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