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Renal nerves and hypertension contribute to impaired proximal tubule megalin-mediated albumin uptake in renovascular hypertensive rats.
Hypertens Res
January 2025
Department of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Proteinuria, especially albuminuria, serves as an independent risk factor for progression in cardiovascular and renal diseases. Clinical and experimental studies have demonstrated that renal nerves contribute to renal dysfunction in arterial hypertension (AH). This study hypothesizes that renal nerves mediate the mechanisms of protein endocytosis by proximal tubule epithelial cells (PTEC) and glomerular function; with dysregulation of the renal nerves contributing to proteinuria in Wistar rats with renovascular hypertension (2-kidney, 1-clip model, 2K-1C).
View Article and Find Full Text PDFHydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma.
bioRxiv
December 2024
Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
The vasodilator hydralazine (HYZ) has been used clinically for ~ 70 years and remains on the World Health Organization's List of Essential Medicines as a therapy for preeclampsia. Despite its longstanding use and the concomitant progress toward a general understanding of vasodilation, the target and mechanism of HYZ have remained unknown. We show that HYZ selectively targets 2-aminoethanethiol dioxygenase (ADO) by chelating its metal cofactor and alkylating one of its ligands.
View Article and Find Full Text PDFHas APOL1 kidney disease treatment been hiding in plain sight?
Kidney Int
December 2024
Department of Medicine, Division of Nephrology and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA. Electronic address:
Two coding variants of APOL1 account for much of the excess risk of focal segmental glomerulosclerosis in people of recent West African ancestry. There is an unmet need of treatment for apolipoprotein L1 kidney disease. In this issue, Sula Karreci et al.
View Article and Find Full Text PDFDrug-Induced Systemic Lupus Erythematosus: A Rare Presentation of Hydralazine-Induced Lupus.
Cureus
October 2024
Internal Medicine, Arrowhead Regional Medical Center, Colton, USA.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by the production of autoantibodies directed against nuclear and cytoplasmic antigens. SLE can be induced by various medications, such as hydralazine, procainamide, isoniazid, methyldopa, chlorpromazine, quinidine, and minocycline. Hydralazine-induced lupus syndrome was first reported in 1953, and only occurs in 5-10% of patients taking hydralazine.
View Article and Find Full Text PDFManifestations of Hydralazine-Induced Vasculitis: A Case Series.
Cureus
October 2024
Internal Medicine, Northeast Georgia Medical Center Gainesville, Gainesville, USA.
Article Synopsis
- Hydralazine has been used for many years to treat high blood pressure, but it can cause serious side effects, including autoimmune diseases like ANCA-vasculitis and a lupus-like syndrome.
- The text discusses four cases of vasculitis linked to hydralazine, showing varying symptoms like lung hemorrhage, coughing up blood, and skin rashes.
- Diagnosing these conditions can be challenging, often requiring kidney biopsy, and the treatment involves stopping hydralazine and using immunosuppressants; caution is advised in using hydralazine over other blood pressure medications.
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