A catalyst-free microwave-assisted annulation protocol for the preparation of biologically interesting pyrido-fused quinazolinones and pyrido[1,2-]benzimidazoles is developed. This reaction involves the [3 + 3] annulation of various quinazolinones or benzimidazoles with 3-formylchromones to yield functionalized 11-pyrido[2,1-]quinazolin-11-one and pyrido[1,2-] benzimidazole derivatives. This approach is successfully extended to the construction of various pyrazolo[4,3-]pyrido[1,2-]pyrimidin-10(1)-ones. The present approach is complementary to the existing synthetic methodologies and offers a rapid and facile approach with a broad substrate scope, good yields, catalyst-free conditions, and a high functional group tolerance. The optimal synthesized compound is also employed as an "on-off" photoluminescent probe for the selective detection of Fe and Ag metal ions.
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