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http://dx.doi.org/10.1038/s41417-022-00458-1 | DOI Listing |
EMBO Rep
January 2025
Department of Biology, University of Konstanz, 78457, Konstanz, Germany.
To ensure the correct euploid state of embryos, it is essential that vertebrate oocytes await fertilization arrested at metaphase of meiosis II. This MII arrest is mediated by XErp1/Emi2, which inhibits the ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome). Cyclin B3 in complex with Cdk1 (cyclin-dependent kinase 1) is essential to prevent an untimely arrest of vertebrate oocytes in meiosis I by targeting XErp1/Emi2 for degradation.
View Article and Find Full Text PDFBiochem Biophys Res Commun
November 2024
School of Life Science and Technology, ShanghaiTech University, Shanghai, China. Electronic address:
In mammalian cells, the Golgi apparatus undergoes fragmentation for its correct partition into two daughter cells during mitosis. Several Golgi structural proteins have been demonstrated to regulate Golgi disassembly/reassembly and spindle formation. However, it is largely unknown whether Golgi proteins mediate other major events in mitosis.
View Article and Find Full Text PDFScience
September 2024
Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK.
Accurate chromosome segregation requires the attachment of microtubules to centromeres, epigenetically defined by the enrichment of CENP-A nucleosomes. During DNA replication, CENP-A nucleosomes undergo dilution. To preserve centromere identity, correct amounts of CENP-A must be restored in a cell cycle-controlled manner orchestrated by the Mis18 complex (Mis18α-Mis18β-Mis18BP1).
View Article and Find Full Text PDFJ Mol Cell Biol
July 2024
MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China School of Life Sciences, Hefei 230027, China.
Stable transmission of genetic information during cell division requires faithful chromosome segregation. Mounting evidence has demonstrated that polo-like kinase 1 (PLK1) dynamics at kinetochores control correct kinetochore-microtubule attachments and subsequent silencing of the spindle assembly checkpoint. However, the mechanisms underlying PLK1-mediated silencing of the spindle checkpoint remain elusive.
View Article and Find Full Text PDFNature
February 2024
INSERM U830, PSL Research University, Institut Curie, Paris, France.
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