Exosomes include plasma-transported vesicles that are secreted by human tissues and reflect metabolic status. The profile of exosomes (particularly microRNA content) is altered in metabolic disease. In type 2 diabetes mellitus, exosomes circulating in plasma induce transcriptional changes related to tumour progression and pro-metastatic phenotypes in target cancer cells, potentially linking obesity to cancer progression and metastasis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152991 | PMC |
| http://dx.doi.org/10.1038/s41574-022-00666-7 | DOI Listing |
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