AI Article Synopsis
- Hypersomnia leads to excessive sleepiness and poor quality of life, and can be caused by various factors, both primary and secondary.
- This text presents three cases where patients with lesions near the paraventricular nucleus in the hypothalamus experienced extreme daytime sleepiness and long nocturnal sleep.
- Treatment of their primary conditions resulted in reduced excessive sleep, highlighting the potential importance of the paraventricular nucleus in hypersomnia.
Article Abstract
Background: Hypersomnia is a common and highly impairing symptom marked by pathological excessive sleepiness, which induces suboptimal functioning and poor quality of life. Hypersomnia can be both a primary (e.g., hypersomnolence disorder) and secondary (e.g., tumors, and head trauma) symptom of disorders. However, its underlying mechanisms remain largely unknown.
Case Presentation: We report that three clinical cases with lesions around the paraventricular nucleus of the hypothalamus (PVH) area showed excessive daytime sleepiness and a prolonged nocturnal sleep lasting more than 20 h per day. Sleep architecture and subjective daytime sleepiness were examined by polysomnography. These cases were presented with stroke, myelin oligodendrocyte glycoprotein (MOG) antibody associated disorders and neuromyelitis optical spectrum disorder (NMOSD), respectively. Magnetic resonance imaging (MRI) showed lesions around the PVH area in all these three patients. After treatment of their primary disorders, their excessive sleep decreased as the PVH area recovered.
Conclusion: Our findings suggest that the PVH may play an essential role in the occurrence of hypersomnia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964012 | PMC |
| http://dx.doi.org/10.3389/fnins.2022.830474 | DOI Listing |
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