AI Article Synopsis
- The study investigated the presence of the opportunistic pathogen subspecies in stool samples from patients with normal colonoscopy, colorectal adenomas, and colorectal cancer.
- Notable findings included a significantly higher prevalence of this pathogen in colorectal cancer patients, along with increased levels of toxinogenic bacteria and other CRC-associated bacteria in their stools.
- The research suggests that the presence and levels of these bacteria change during the stages of colorectal cancer, with the specific pathogen identified as significant even at the early adenoma stage.
Article Abstract
Purpose: subspecies () is an opportunistic pathogen causing invasive infections in the elderly often associated with colon neoplasia. The prevalence of in the stools of patients with normal colonoscopy (control) was compared with patients with colorectal adenomas (CRA) or with carcinomas (CRC) from stages I to IV. The presence of the s island encoding colibactin as well as other CRC-associated bacteria such as toxicogenic , , and was also investigated.
Patients And Methods: Fecal samples collected in France between 2011 and 2016 from patients with normal colonoscopy ( = 25), adenoma ( = 23), or colorectal cancer at different stages ( = 81) were tested by PCR for the presence of , , , , and the island. Relative quantification of , , and in stools was performed by qPCR.
Results: prevalence was significantly increased in the CRC group. Our results also revealed i) a strong and significant increase of toxinogenic in patients with early-stage adenoma and of island at late-stage CRC and ii) increased levels of and in the stools of CRC patients. Furthermore, the simultaneous detection of these five bacterial markers was only found in CRC patients.
Conclusions: Our results indicate that the prevalence or relative levels of CRC-associated bacteria vary during CRC development. Among them, (+) was singled out as the sole pathobiont detected at the early adenoma stage.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963412 | PMC |
| http://dx.doi.org/10.3389/fcimb.2022.794391 | DOI Listing |
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