AI Article Synopsis
- Ferroptosis is a newly identified type of programmed cell death linked to glioblastoma tumor growth and progression.
- The study analyzed 516 glioblastoma samples, exploring how ferroptosis-related genes (FRGs) are expressed, mutated, and show copy number variations (CNVs), identifying three distinct regulation patterns.
- A prognostic model was created using five FRGs that can predict patient outcomes and gauge immune responses, potentially informing future research and the development of new tools for predicting prognosis in glioblastoma patients.
Article Abstract
Ferroptosis, a recently discovered regulated programmed cell death, is associated with tumorigenesis and progression in glioblastoma. Based on widely recognized ferroptosis-related genes (FRGs), the regulation of ferroptosis patterns and corresponding characteristics of immune infiltration of 516 GBM samples with GSE13041, TCGA-GBM, and CGGA-325 were comprehensively analyzed. Here, we revealed the expression, mutations, and CNV of FRGs in GBM. We identified three distinct regulation patterns of ferroptosis and found the hub genes of immunity and stemness among DEGs in three patterns. A prognostic model was constructed based on five FRGs and verified at the mRNA and protein level. The risk score can not only predict the prognosis but also the degree of immune infiltration and ICB responsiveness by functional annotation. The overall assessment of FRGs in GBM patients will guide the direction of improved research and develop new prognostic prediction tools.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960280 | PMC |
| http://dx.doi.org/10.3389/fneur.2022.829926 | DOI Listing |
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