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Multifocality increases the risk of central compartment lymph node metastasis but is not related to the risk of recurrence and death in papillary thyroid carcinoma.
Gland Surg
December 2024
Department of Thyroid and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Background: Multifocality is a distinctive feature of papillary thyroid carcinoma (PTC); however, the biological behavior of PTC and its optimal management strategy remain unclear. The aim of this study was to analyze the clinical features and prognostic differences of multifocal papillary carcinoma and to guide the precise treatment of multifocal papillary carcinoma.
Methods: The medical records of 1,139 patients with PTC who had undergone total or hemi-thyroidectomy between April and October 2013 at the Tianjin Medical University Cancer Institute and Hospital were reviewed.
Compartmental location of middle ear inflammatory polyps in cats: 9 cases (2021-2023).
J Small Anim Pract
January 2025
Surgical Unit, Centre Hospitalier Vétérinaire St Martin, Allonzier La Caille, France.
Objectives: To report the compartmental location of feline aural inflammatory polyps within the tympanic bulla.
Materials And Methods: Nine client-owned cats with clinical signs and middle ear filling consistent with feline aural inflammatory polyps were prospectively pre-selected and underwent unilateral or bilateral ventral bulla osteotomy. Preoperative and surgical findings, complications and outcomes were recorded.
Microstructural Degeneration of the Corpus Callosum in Parkinson's Disease with Unilateral Onset: A Free-Water Imaging Study.
ACS Chem Neurosci
January 2025
Department of Radiology, The Second Affiliated Hospital, Zhejiang University of Medicine, Hangzhou 310009, China.
Article Synopsis
- Motor symptom laterality in Parkinson's Disease (PD) impacts both motor and nonmotor symptoms, potentially altering patient prognosis, with compensatory mechanisms in the brain's dominant hemisphere playing a key role.
- This study investigated the microstructural changes in the corpus callosum (CC), the brain's main connector between hemispheres, in 201 right-handed PD patients (split between left- and right-onset) compared to 100 healthy controls using advanced imaging techniques.
- Findings revealed reduced free water and fractional anisotropy, along with increased mean diffusivity in the CC of patients with left-side PD onset, highlighting the relationship between brain structure and disease symptoms.
Endothelial-specific deletion of connexin 43 improves renal function and structure after acute kidney injury.
Mol Med
December 2024
Batiment Recherche, INSERM UMR S1155, Tenon Hospital, 4 rue de la Chine, 75020, Paris, France.
Background: We have previously reported that the gap junction protein connexin 43 (Cx43) was upregulated in chronic renal disease in humans and rodents and plays a crucial role in the progression of experimental nephropathy. In this study, we investigated its role after renal ischemia/reperfusion (rIR), which is a major mechanism of injury in acute renal injury (AKI) and renal transplant graft dysfunction.
Methods: Wild-type mice (WT) and mice in which Cx43 expression was genetically reduced by half (Cx43 ±) were unilaterally nephrectomized.
Is endolymphatic hydrops, as detected in MRI, a truly cochleocentric finding?
Front Neurol
December 2024
Department of Radiology, Clínica Universidad de Navarra, Madrid, Spain.
Introduction: The most common histopathological finding in Ménière's disease (MD) is endolymphatic hydrops (EH), which involves the dilation of the membranous labyrinth. The direct relationship between EH and MD is debated, although EH plays a crucial role in auditory and vestibular functional tests. MRI sequences such as 3D-FLAIR and 3D-real-IR are used to study EH, with the latter being more effective.
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