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The Efficacy and Safety of Durvalumab and Tremelimumab with Concomitant Treatment for MSS/pMMR Metastatic Colorectal Cancer: A Single Arm Meta-Analysis.
J Gastrointest Cancer
January 2025
Computer Science, Changchun University of Science and Technology, Changchun, 130022, Jilin, China.
Objectives: To address the issue that most microsatellite-stable (MSS) and proficient mismatch repair (pMMR) metastatic colorectal cancer (mCRC) patients have minimal response to immunotherapy, this meta-analysis evaluated the efficacy and safety of durvalumab and tremelimumab with concomitant treatment in treating MSS/pMMR metastatic colorectal cancer.
Methods: All included trials were prospective studies with a median patient age of 63 years, of which 94.2% were MSS/pMMR mCRC patients, with a male to female ratio of 1.
[Indications and limitations of conservative and invasive treatment of the inflammatory shoulder joint and the shoulder girdle].
Z Rheumatol
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Abteilung Orthopädische Rheumatologie, Vitos Orthopädische Klinik Kassel, Wilhelmshöher Allee 345, 34131, Kassel, Deutschland.
An inflammatory rheumatic shoulder can be assessed as a forgotten joint. Apparent problems and deformities of the hands and feet are prioritized in the perception of rheumatic patients. In contrast, however, involvement of the shoulder joint in the context of an inflammatory rheumatic disease is very high with up to 85% [2].
View Article and Find Full Text PDFA structural health monitoring data reconstruction method based on VMD and SSA-optimized GRU model.
Sci Rep
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School of Civil Engineering, Qingdao University of Technology, Qingdao, 266525, China.
In the field of Structural Health Monitoring (SHM), complete datasets are fundamental for modal identification analysis and risk prediction. However, data loss due to sensor failures, transmission interruptions, or hardware issues is a common problem. To address this challenge, this study develops a method combining Variational Mode Decomposition (VMD) and Sparrow Search Algorithm (SSA)-optimized Gate Recurrent Unit (GRU) for recovering structural response data.
View Article and Find Full Text PDFEffect of sofosbuvir and daclatasvir treatment on the blood indices in patients with chronic hepatitis C virus.
Arab J Gastroenterol
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Endemic Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Background And Study Aims: Hepatitis C virus (HCV) infection is a significant problem in Egypt, as it is associated with various hematological disorders, both benign and malignant. In Egypt, direct-acting antivirals (DAAs) serve as the principal therapy for HCV to achieve a sustained virological response (SVR). This study investigated the effects of sofosbuvir (SOF) and daclatasvir (DCV) on HCV patients with benign blood index abnormalities and examined the correlation between these abnormalities and SVR.
View Article and Find Full Text PDFBeing a "Lay Expert": A Choice for Chinese Parents of Young Autistic Children.
Intellect Dev Disabil
February 2025
Yumin Zhang, Ningbo University, China, Junting Chen, Nanchong Vocational College of Science and Technology, and Xiaoyan Li, Wenzhou University, China.
The lack of rehabilitation teachers for autistic children is common in lower-middle income countries. Designing programs to train parents to become "para-rehabilitators," that is, "lay experts," is one of the ways to solve this problem. The purpose of this study was to explore the feelings, problems, and hopes of Chinese parents participating in the parent-implemented rehabilitation model.
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