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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076409 | PMC |
| http://dx.doi.org/10.1152/advan.00016.2022 | DOI Listing |
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Engaging today's undergraduate students in the field of dairy science with a focus on the female student population.
JDS Commun
January 2025
Department of Animal and Food Science, University of Wisconsin-River Falls, River Falls, WI 54022.
The dairy industry has profound economic importance, and individuals earning postsecondary degrees within dairy science-related fields are future industry leaders. Yet, enrollment at universities is declining and there is a labor shortage within the dairy industry. The objective of this review article is to highlight current trends within academia, identify some techniques to improve student experiences within higher education, and describe successful education strategies employed within dairy science-related fields.
View Article and Find Full Text PDFEvaluation of an Interdisciplinary Educational Program to Foster Learning Health Systems: Education Evaluation.
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Centre for Digital Transformation of Health, University of Melbourne, Carlton, Australia.
Background: Learning health systems (LHS) have the potential to use health data in real time through rapid and continuous cycles of data interrogation, implementing insights to practice, feedback, and practice change. However, there is a lack of an appropriately skilled interprofessional informatics workforce that can leverage knowledge to design innovative solutions. Therefore, there is a need to develop tailored professional development training in digital health, to foster skilled interprofessional learning communities in the health care workforce in Australia.
View Article and Find Full Text PDFFrom Radical Coupling to Enantioselective Controlled Protonation: Advancing Precise Construction of Stereocenters.
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Henan Key Laboratory of Natural Medicine Innovation and Transformation, Henan University, Kaifeng, Henan 475004, PR China.
Recent advancements in green and sustainable platforms, particularly visible light-driven photocatalysis, have spurred significant progress in radical chemistry, enabling the efficient synthesis of important molecules from simple and readily available feedstocks under mild conditions. However, the rapid orbital flipping and high reactivity of radicals pose substantial challenges for achieving precise enantiocontrol in stereocenter formation via radical coupling. In this study, we present a generic and efficient strategy that modulates this elusive approach, facilitating enantiocontrollable protonation through 1,3-boron migration.
View Article and Find Full Text PDFConformational flexibility of human ribokinase captured in seven crystal structures.
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January 2025
Department of Biochemistry, Memorial University of Newfoundland, 45 Arctic Avenue, St. John's, Newfoundland and Labrador, Canada. Electronic address:
d-ribose is a critical sugar substrate involved in the biosynthesis of nucleotides, amino acids, and cofactors, with its phosphorylation to ribose-5-phosphate by ribokinase (RK) constituting the initial step in its metabolism. RK is conserved across all domains of life, and its activity is significantly enhanced by monovalent metal (M) ions, particularly K, although the precise mechanism of this activation remains unclear. In this study, we present several crystal structures of human RK in both unliganded and substrate-bound states, offering detailed insights into its substrate binding process, reaction mechanism, and conformational changes throughout the catalytic cycle.
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