Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00234-022-02936-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Adolescent cerebellar nuclei manipulation alters reversal learning and perineuronal net intensity independently in male and female mice.
J Neurosci
January 2025
Arizona State University, Department of Psychology, Tempe, AZ, 85287 USA.
The cerebellum, identified to be active during cognitive and social behavior, has multisynaptic connections through the cerebellar nuclei (CN) and thalamus to cortical regions, yet formation and modulation of these pathways are not fully understood. Perineuronal nets (PNNs) respond to changes in local cellular activity and emerge during development. PNNs are implicated in learning and neurodevelopmental disorders, but their role in the CN during development is unknown.
View Article and Find Full Text PDFCurvature Dependence of Gravitational-Wave Tests of General Relativity.
Phys Rev Lett
December 2024
Center for Computational Astrophysics, Flatiron Institute, 162 5th Avenue, New York, New York 10010, USA.
High-energy extensions to general relativity modify the Einstein-Hilbert action with higher-order curvature corrections and theory-specific coupling constants. The order of these corrections imprints a universal curvature dependence on observations while the coupling constant controls the deviation strength. In this Letter, we leverage the theory-independent expectation that modifications to the action of a given order in spacetime curvature (Riemann tensor and contractions) lead to observational deviations that scale with the system length scale to a corresponding power.
View Article and Find Full Text PDFBackbone extraction through statistical edge filtering: A comparative study.
PLoS One
January 2025
LIB, Université de Bourgogne, Franche-Comté, Dijon, France.
The backbone extraction process is pivotal in expediting analysis and enhancing visualization in network applications. This study systematically compares seven influential statistical hypothesis-testing backbone edge filtering methods (Disparity Filter (DF), Polya Urn Filter (PF), Marginal Likelihood Filter (MLF), Noise Corrected (NC), Enhanced Configuration Model Filter (ECM), Global Statistical Significance Filter (GloSS), and Locally Adaptive Network Sparsification Filter (LANS)) across diverse networks. A similarity analysis reveals that backbones extracted with the ECM and DF filters exhibit minimal overlap with backbones derived from their alternatives.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Huashan Hospital, Fudan University, Shanghai, Shanghai, China.
Background: Cognition and its two critical proxies, socioeconomic status (SES) and educational attainment (EA), contribute substantially to human health and are heritable. Elucidating the genetic characteristics of SES/EA/Cognition not only helps to understand the innate individual differences in cognition, but also aids in unraveling the biological mechanisms of complex cognitive-related disorders such as Alzheimer's disease (AD). Here, we explored the rare and common protein-coding variants impacting the comprehensive cognition phenotypic spectrum by leveraging large-scale exomes.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of California, Irvine, Irvine, CA, USA.
Background: Alzheimer's disease (AD), characterized by tau lesions and amyloid plaques, has traditionally been investigated within the cortical domain. Recent neuroimaging studies have implicated micro- and macrostructural abnormalities in cortical layers during the progression of AD. While examinations from diverse brain regions have contributed to comprehending the regional severity, these approaches have constrained the ability to delineate cortical alterations in AD.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!