AI Article Synopsis
- * A case study details a 66-year-old man with hepatitis C who developed MPGN and a 5-year-old boy who presented with aHUS after an infection, both sharing similar genetic variants.
- * The findings suggest that low levels of factor H-related 5 (FHR-5) may increase susceptibility to infections, leading to different kidney disease manifestations.
Article Abstract
Dysregulation of the alternative complement pathway is a major pathogenic mechanism in two rare renal diseases: atypical haemolytic uraemic syndrome (aHUS) and membranoproliferative glomerulonephritis (MPGN). We report on a 66-year-old male with chronic hepatitis C virus (HCV) infection and a combined liver-kidney transplant that was diagnosed with MPGN at the age of 63 years and a 5-year-old boy who presented with aHUS at the age of 21 months following a infection. Both patients carried similar frameshift variants in the complement gene that segregate with reduced levels of factor H-related 5 (FHR-5). We conclude that low FHR-5 levels may predispose to viral and bacterial infections that then trigger different renal phenotypes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962748 | PMC |
| http://dx.doi.org/10.1093/ckj/sfaa004 | DOI Listing |
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Article Synopsis
- Hemolytic uremic syndrome (HUS) is a serious condition that can happen after an infection or due to problems in the body's immune system, and there are two types: typical and atypical.
- This text discusses a 9-year-old boy who had a rare form of aHUS caused by specific genetic issues, which made his body produce autoantibodies that affected his kidneys and brain.
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