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Semiautomated Production of Cell-Free Biosensors.
ACS Synth Biol
March 2025
Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States.
Cell-free synthetic biology biosensors have potential as effective diagnostic technologies for the detection of chemical compounds, such as toxins and human health biomarkers. They have several advantages over conventional laboratory-based diagnostic approaches, including the ability to be assembled, freeze-dried, distributed, and then used at the point of need. This makes them an attractive platform for cheap and rapid chemical detection across the globe.
View Article and Find Full Text PDFAssessing Total Hip Arthroplasty Outcomes and Generating an Orthopedic Research Outcome Database via a Natural Language Processing Pipeline: Development and Validation Study.
JMIR Med Inform
March 2025
LynxCare Inc, Leuven, Belgium.
Background: Processing data from electronic health records (EHRs) to build research-grade databases is a lengthy and expensive process. Modern arthroplasty practice commonly uses multiple sites of care, including clinics and ambulatory care centers. However, most private data systems prevent obtaining usable insights for clinical practice.
View Article and Find Full Text PDFThe development of targeted therapy for patients with multiple myeloma (MM) is hampered by the low frequency of actionable genetic abnormalities. Gain or amplification of chromosome 1q (1q+) is the most frequent arm-level copy number gain in patients with MM and is associated with higher risk of progression and death despite recent therapeutic advances. Thus, developing targeted therapy for MM patients with 1q+ stands to benefit a large portion of patients in need of more effective management.
View Article and Find Full Text PDFWorldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients.
Oncotarget
March 2025
Worldwide Innovative Network (WIN) Association - WIN Consortium, Chevilly-Larue, France.
The human genome project ushered in a genomic medicine era that was largely unimaginable three decades ago. Discoveries of druggable cancer drivers enabled biomarker-driven gene- and immune-targeted therapy and transformed cancer treatment. Minimizing treatment not expected to benefit, and toxicity-including financial and time-are important goals of modern oncology.
View Article and Find Full Text PDFEffect of Diethanolamine after Carbon Dioxide Absorption and Desorption on Mechanical Strength of Cement Mortar and Mechanism.
Langmuir
March 2025
Tianjin Building Materials Group (Holding) Corporation, Tianjin 300381, China.
Diethanolamine (DEA) can be used not only as a cement admixture but also to capture carbon dioxide (CO). However, the waste liquid treatment still faces the problems of high energy consumption and increasing environmental burden. The effects of DEA waste liquid (WL-DEA) with multiple cycles of CO absorption and desorption on the setting time, hydration temperature, mechanical strength, and microstructure of cement-based materials were explored.
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