Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967007 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0266629 | PLOS |
Publication Analysis
Top Keywords
retraction naloxone's
4
naloxone's pentapeptide
4
pentapeptide binding
4
binding site
4
site filamin
4
filamin blocks
4
blocks opioid
4
opioid receptor-gs
4
receptor-gs coupling
4
coupling creb
4
Similar Publications
Naloxone's pentapeptide binding site on filamin A blocks Mu opioid receptor-Gs coupling and CREB activation of acute morphine.
PLoS One
May 2009
Department of Physiology & Pharmacology, City University of New York Medical School, New York, New York, United States of America.
Chronic morphine causes the mu opioid receptor (MOR) to switch its coupling from Gi/o to Gs, resulting in excitatory signaling via both Galphas and its Gbetagamma dimer. Ultra-low-dose naloxone (NLX) prevents this switch and attenuates opioid tolerance and dependence. This protective effect is mediated via a high-affinity interaction of NLX to a pentapeptide region in c-terminal filamin A (FLNA), a scaffolding protein interacting with MOR.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!