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Urine biomarkers can predict prostate cancer and PI-RADS score prior to biopsy.
Sci Rep
August 2024
Department of Urology, University Hospital of Zürich, Frauenklinikstrasse 10, 8091, Zürich, Switzerland.
Prostate-Specific Antigen (PSA) based screening of prostate cancer (PCa) needs refinement. The aim of this study was the identification of urinary biomarkers to predict the Prostate Imaging-Reporting and Data System (PI-RADS) score and the presence of PCa prior to prostate biopsy. Urine samples from patients with elevated PSA were collected prior to prostate biopsy (cohort = 99).
View Article and Find Full Text PDFA comparative urinary proteomic and metabolomic analysis between renal aa amyloidosis and membranous nephropathy with clinicopathologic correlations.
J Proteomics
February 2024
Hacettepe University Faculty of Medicine, Department of Nephrology, Ankara, Turkey.
Urinary omics has become a powerful tool for elucidating pathophysiology of glomerular diseases. However, no urinary omics analysis has been performed yet on renal AA amyloidosis. Here, we performed a comparative urine proteomic and metabolomic analysis between recently diagnosed renal AA amyloidosis (AA) and membranous nephropathy (MN) patients.
View Article and Find Full Text PDFKidney stone matrix proteins: Role in stone formation.
World J Nephrol
March 2023
Department of Nephrology, Instituto de Investigaciones Metabólicas, Buenos Aires 1012, Argentina.
Stone formation is induced by an increased level of urine crystallization promoters and reduced levels of its inhibitors. Crystallization inhibitors include citrate, magnesium, zinc, and organic compounds such as glycosaminoglycans. In the urine, there are various proteins, such as uromodulin (Tamm-Horsfall protein), calgranulin, osteopontin, bikunin, and nephrocalcin, that are present in the stone matrix.
View Article and Find Full Text PDFGlycosaminoglycan linkage region of urinary bikunin as a potentially useful biomarker for β3GalT6-deficient spondylodysplastic Ehlers-Danlos syndrome.
JIMD Rep
September 2022
Department of Laboratory Medicine, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
The spondylodysplastic type of Ehlers-Danlos syndrome (spEDS) is caused by genetic defects in the or genes both deranging the biosynthesis of the glycosaminoglycan linkage region of chondroitin/dermatan sulfate and heparan sulfate proteoglycans. In this study, we have analyzed the linkage regions of urinary chondroitin sulfate proteoglycans of three siblings, diagnosed with spEDS and carrying biallelic pathogenic variants of the gene. Proteoglycans were digested with trypsin, glycopeptides enriched on anion-exchange columns, depolymerized with chondroitinase ABC, and analyzed by nLC-MS/MS.
View Article and Find Full Text PDFUrine protein in patients with type I hypersensitivity is indicative of reversible renal tube injury.
Life Sci
September 2022
School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. Electronic address:
Aims: In our clinical work, some patients with type I hypersensitivity could be detected protein in their urine. This study focused on the early renal injury in patients with type I hypersensitivity.
Main Methods: From 43 type I hypersensitivity patients with proteinuria, 10 patients were randomly selected for mass spectrometry analysis of 24-h urine together with 5 healthy volunteers.
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