Molecular Networking-Driven Discovery of Antibacterial Perinadines, New Tetracyclic Alkaloids from the Marine Sponge-Derived Fungus sp.

Two rare tetracyclic skeleton alkaloids named perinadines B and C ( and ) were isolated as mixtures of epimers from the marine-derived sp. LS116 driven by molecular networking. The planar structures of and were characterized by comprehensive spectroscopic data. Additionally, compounds and showed moderate antibacterial activity against with minimum inhibitory concentration values of 32 and 64 μg/mL, respectively. Besides, both of the compounds were evaluated for anti-inflammatory activities in an zebra fish model.