MoS/LaF for enhanced photothermal therapy performance of poorly-differentiated hepatoma.

Photothermal therapy (PTT) based on nanoparticle had been widely used to antitumor treatment. However, low photothermal conversion efficiency (PCE) is the main hurdle for antitumor treatment. To improve the PCE and gain ideal clinical the nanoparticle with higher photothermal conversion efficiency, we have developed a highly efficient solar absorber with MoS/LaF/ polydimethylsiloxane(PDMS) which can enhance the absorption of solar irradiation engergy, however, its photothermal effect irradiated by near-infrared light has not yet been investigated. The knowledge absence in photothermal effect will impede MoS/LaF/PDMS to be used for cancer therapy in clinic. In this study, we applied LaF-loaded, MoS-based photothermal conversion agents (PTAs) for improved photothermal cancer therapy. The study showed that the MoS/LaF nanoflowers showed higher photothermal conversion efficiency (PCE, 42.5%) and could more effectively inhibit cancer cell proliferation compared to MoS-based PTT agents in vitro. In vivo, the results further revealed that photothermal therapy using MoS/LaF nanoflowers could significantly inhibit solid tumor growth. The study clearly demonstrated that MoS/LaF could work at under low power NIR Laser in vitro and in vivo, resulting in a very impressive therapeutic effect in tumor-bearing mice. The MoS/LaF nanoflowers will be prominent candidate nanoparticle for effective inhibiting tumor growth by photothermal therapy.