Osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), is the most reliable EGFR-TKI and is widely used as the first-line treatment for EGFR mutation-positive non-small cell lung cancer. Pigmentary changes caused by EGFR-TKIs are unusual, and to the best of my knowledge, hyperpigmentation with osimertinib has rarely been reported as a skin-related adverse event. Here, I report a case of osimertinib-associated ashy dermatosis-like hyperpigmentation on imaging. Although reducing the dose of osimertinib to 40 mg did not improve pigmentation, osimertinib use was continued due to its clinical and radiological benefit, which persisted for a long time.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058305 | PMC |
http://dx.doi.org/10.1111/1759-7714.14383 | DOI Listing |
JMIR Dermatol
November 2024
Department of Dermatology, De La Salle Medical and Health Sciences Institute, Dasmariñas, Cavite, Philippines.
Thorac Cancer
May 2022
First Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Ribociclib is a selective cyclin-dependent kinase (CDK) 4/6 inhibitor that has been approved in combination with endocrine therapy for the treatment of hormone receptor-positive/human epidermal growth factor 2-negative advanced or metastatic breast cancer. The main dermatological adverse events associated with CDK 4/6 inhibitors that are described in the literature include skin rash, an increased risk of alopecia, and stomatitis. Erythema dyschromicum perstans (EDP), also known as ashy dermatosis, is characterized by acquired small and large slate-gray hyperpigmented macules with erythematous borders.
View Article and Find Full Text PDFJAAD Case Rep
September 2020
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
JAAD Case Rep
February 2020
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Skin and Allergy Research Unit, Chulalongkorn University, Bangkok, Thailand.
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