Conventional chemical and even electrochemical Birch-type reductions suffer from a lack of chemoselectivity due to a reliance on alkali metals or harshly reducing conditions. This study reveals that a simpler avenue is available for such reductions by simply altering the waveform of current delivery, namely rapid alternating polarity (rAP). The developed method solves these issues, proceeding in a protic solvent, and can be easily scaled up without any metal additives or stringently anhydrous conditions.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216236 | PMC |
| http://dx.doi.org/10.1021/jacs.2c02102 | DOI Listing |
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