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Correlation between polymorphisms of gene and renal injury in patients with type 2 diabetes mellitus.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
July 2024
Department of Nephrology, Third Xiangya Hospital, Central South University, Changsha 410013.
Objectives: Genetic factors play an important role in the pathogenesis of diabetic kidney disease (DKD). Studies have shown that gene polymorphism is associated with the pathogenesis of type 2 diabetes mellitus (T2DM), but its role in DKD remains unclear. This study aims to analyze the distribution of alleles and genotypes of gene in patients with T2DM, and investigate the association between genetic polymorphism and DKD susceptibility in T2DM patients, which may provide new ideas for the pathogenesis of DKD.
View Article and Find Full Text PDFAssociation between dietary fructose and human colon DNA methylation: implication for racial disparities in colorectal cancer risk using a cross-sectional study.
Am J Clin Nutr
January 2025
Department of Family Medicine, University of Virginia, Charlottesville, VA, USA; University of Virginia Comprehensive Cancer Center, University of Virginia, Charlottesville, VA, USA. Electronic address:
Background: An increasing body of evidence has linked fructose intake to colorectal cancer (CRC). African American (AA) adults consume greater quantities of fructose and are more likely to develop right-side colon cancer than European American (EA) adults.
Objective: We examined the hypothesis that fructose consumption leads to epigenomic and transcriptomic differences associated with CRC tumor biology.
Blood DNA methylation biomarkers for cognitive decline in older adults with type 2 diabetes.
Alzheimers Dement
December 2024
The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel
Background: Type 2 diabetes (T2D) is a recognized risk factor for dementia. This study aimed to pinpoint blood DNA methylation biomarkers for cognitive decline in older adults with T2D by comparing those who developed dementia with those who remained cognitively normal during follow‐up
Method: Illumina Infinium MethylationEPIC microarray was used for the initial 24 couples and Infinium HumanMethylationEPIC microarray version 2.0 for the subsequent 8 couples.
Whole genome methylation sequencing in blood identifies extensive differential DNA methylation in mild cognitive impairment (MCI).
Alzheimers Dement
December 2024
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Background: Whole genome methylation sequencing (WGMS) in blood identifies extensive differential DNA methylation between persons who are cognitively unimpaired (CU) and those with late‐onset dementia due to Alzheimer’s disease (AD). Here we investigate differentially methylated positions (DMPs) in persons with mild cognitive impairment (MCI) compared to persons with and without AD.
Method: WGMS data quantified DNA methylation levels at 25,406,945 CpG loci in 382 blood samples from 99 persons with MCI, 109 persons with AD and 174 cognitively unimpaired persons in the Wisconsin Alzheimer’s Disease Research Center (WADRC) and the Wisconsin Registry for Alzheimer’s Prevention (WRAP).
Impact of TDP‐43 co‐pathology on limbic cortical microstructure in Alzheimer’s disease: evidence from an autopsy‐confirmed cohort with in vivo diffusion MRI.
Alzheimers Dement
December 2024
University of Southern California, Los Angeles, CA, USA
Background: TDP‐43 (TAR DNA‐binding protein 43) is one of the most frequently observed co‐pathologies in Alzheimer's disease (AD). Recognizing the diversity of pathological features in individuals with AD, including the presence of TDP‐43, may lead to more personalized and effective treatment approaches. We investigate ante‐mortem cortical microstructural changes in MRI with subsequent autopsy confirmation of Alzheimer’s disease neuropathological changes (ADNC) with and without TDP‐43 comorbidity.
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