AI Article Synopsis
- Fungi are diverse eukaryotic organisms that have important roles in both health and disease, including their impact on the human mycobiome.
- Recent research has focused on the oral mycobiome and its potential link to oral cancer, specifically investigating Candida albicans, a common oral fungus.
- This review discusses various models exploring how the oral mycobiome might influence oral dysplasia and cancer, highlighting the need for more mechanistic studies in this area.
Article Abstract
Fungi, a diverse group of eukaryotic organisms, play distinct roles in health and disease. Recent advances in the field of mycobiology have enabled the characterization of the "human mycobiome." The human mycobiome has extensively been studied in various disease models. However, to date, the role of the oral mycobiome in oral carcinogenesis has yet to be elucidated. Candida albicans, the most common oral colonizer, has been speculated to display tumorigenic effects; however, the literature lacks consistent documentation from mechanistic studies on whether oral mycobiota act as drivers, facilitators, or passive colonizers of oral premalignancy and cancer. This review article provides an overview of existing hypothesis-driven mechanistic models that outline the complex interplay between the oral mycobiome and oral epithelial dysplasia as well as their potential clinical implications.
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| http://dx.doi.org/10.1111/jop.13295 | DOI Listing |
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