Estimating adults and children's potential health risks to heavy metals in water through ingestion and dermal contact in a rural area, Northern Tunisia.

High concentrations of heavy metals (HMs) in water (e.g., As, Cr, and Cd) are harmful to human health, especially to children. HMs' (As, Cd, Mn, Fe, Cu, Hg, Zn, Cr, and Se) values have been determined from the water of the Guenniche plain (Tunisia); then the carcinogenic risk (CR) and non-carcinogenic Risk (N-CR) were estimated through ingestion and dermal contact for adults and children. The analysis results show that the Hg, As, and Cd in 50% of the ephemeral streams (ESs) exceeded one of the WHO and NT guidelines for safe water, as is the case with Hg and Cd in 25% of the shallow groundwater wells (SGW). In all samples, the N-CR of all HMs, and the CR due to the dermal contact controlled by As, for both age brackets, are deemed to fall far short of the threshold set by USEPA. The CR due to the ingestion pathway caused by As, Cr, and Cd contamination indicates a "high" to "very high" risk on its users in roughly 50% of all the samples (ESs and SGW) for both age brackets by exceeding 10. Overall, the SGW samples close to the floodplain area of the ESs pose a real CR to both age groups, which is more serious for children. Therefore, the SGW are not recommended for drinking use, with an urgent call for a solution by the policy-makers to improve the water quality of the region.