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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Department of Neurology, Columbia University, New York, NY, USA.
Article Synopsis
- Lipid dysregulation and TDP-43 inclusions are linked to cognitive impairment in Alzheimer's Disease (AD), with TDP-43 found in 57% of AD patients suggesting a possible role in disease severity.
- TARDBP, a gene implicated in AD and ALS, was knocked down in cultured monocyte-derived microglia (MDMi), revealing its significant impact on cholesterol metabolism and immune responses.
- The findings suggest that TDP-43 inclusions may worsen AD by disrupting cholesterol homeostasis through TARDBP loss of function, which potentially affects microglial functions.
Reader Response: Distribution of Silent Cerebral Infarcts in Adults With Sickle Cell Disease.
Neurology
January 2025
(Havana, Cuba).
Improved doramectin production based on high-throughput screening and medium optimization in .
Prep Biochem Biotechnol
January 2025
College of Chemical Engineering, Shijiazhuang University, Shijiazhuang, Hebei Province, China.
Doramectin, a 16-membered macrocyclic lactone that is widely used in the treatment of mammalian parasitic diseases. Doramectin was produced by mutant using cyclohexanecarboxylic acid as a precursor. As a semi-synthetic insecticidal agent produced, the production of doramectin was low, which could not be satisfy the demands of industrial fermentation.
View Article and Find Full Text PDFDiagnostic accuracy and inter-reader agreement of the nacVI-RADS for bladder cancer treated with neoadjuvant chemotherapy: a prospective validation study.
Eur Radiol
December 2024
Department of Radiological Sciences, Oncology and Pathology, Sapienza University/Policlinico Umberto I, Rome, Italy.
Objective: The primary aim was to determine the performance of neoadjuvant chemotherapy VI-RADS (nacVI-RADS) in predicting response to systemic therapy in patients with MIBC and to evaluate its inter-reader agreement.
Materials And Methods: Prospective study, including patients with non-metastatic muscle-invasive bladder cancer (MIBC) who underwent neoadjuvant chemotherapy before radical cystectomy (RC). Patients underwent pre- and post-treatment MRI.
Attenuation of neutrophil adhesion and formation of neutrophil extracellular traps by pooled human immune globulins.
Front Pharmacol
December 2024
Department of Ophthalmology, Loyola University Chicago, Maywood, IL, United States.
Introduction: This study investigated the efficacy of pooled human immune globulins (Flebogamma DIF) to combat the formation of neutrophil extracellular traps (NETs) and NETosis, along with neutrophil adhesion to corneal epithelial cells in response to dry eye disease relevant stimuli.
Methods: Human neutrophils were isolated by bead-based immunomagnetic depletion of non-target cells from human whole blood. NETosis was induced using phorbol 12-myristate 13-acetate (PMA) or anti-citrullinated histone 4 R3 antibody (H4R3 ACPA).
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