AI Article Synopsis
- Researchers observed that miR-1-3p is significantly lower in gastric cancer (GC) tissue compared to normal tissue, indicating its potential role in GC progression.
- Overexpressing miR-1-3p reduced harmful cell behaviors in GC, while inhibiting it increased these behaviors, suggesting miR-1-3p's protective role in cancer growth.
- The study also found that miR-1-3p interacts with the CENPF gene, lowering its expression, which points to CENPF as a possible target for future GC treatments.
Article Abstract
Here we noted significantly downregulated miR-1-3p in gastric cancer (GC) tissue compared with adjacent normal tissue through qRT-PCR. Lowly expressed miR-1-3p correlated GC progression. Overexpressing miR-1-3p could restrain tumor-relevant cell behaviors in GC, while miR-1-3p inhibitor treatment triggered the opposite results. Moreover, dual-luciferase reporter gene detection identified specific binding sites of miR-1-3p in CENPF 3'untranslated region. Upregulating miR-1-3p constrained cell progression of GC via CENPF downregulation. Western blot, qRT-PCR and dual-luciferase detections manifested that miR-1-3p negatively mediated CENPF expression in GC cells. Thus, we demonstrated that miR-1-3p negatively mediated CENPF to hamper GC progression. CENPF may be an underlying target for GC therapy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961954 | PMC |
| http://dx.doi.org/10.1186/s12876-022-02203-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!