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Similarities of metabolomic disturbances in prematurity-associated obstructive lung disease to chronic obstructive pulmonary disease.
Sci Rep
October 2024
Department of Child Health, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
Prematurity-associated lung disease (PLD) is a long-term consequence of preterm-birth. Since the underlying mechanisms of PLD remain poorly characterised, we compared the urinary metabolome between recently described spirometry phenotypes of PLD. Preterm- and term-born children aged 7-12 years, from the Respiratory Health Outcomes in Neonates (RHiNO) cohort, underwent spirometry and urine collection.
View Article and Find Full Text PDFPrematurity-associated lung disease: is it asthma?
ERJ Open Res
May 2024
Children's Lung Health, Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth Children's Hospital, Nedlands, Australia.
https://bit.ly/3Tko3vi.
View Article and Find Full Text PDFComprehensive pulmonary function analysis identifies predominant obstructive phenotype in former premature infants around one year of age.
Pediatr Pulmonol
December 2024
Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
Background: Preterm infants suffer from significant respiratory morbidity during the first years of life, but the underlying lung pathophysiology is not fully understood. This study aimed to comprehensively characterize the pulmonary functions of preterm infants using full infant pulmonary function testing (iPFT).
Methods: Between 2008 and 2019, we recruited 150 infants (M 10.
Long-term respiratory consequences of prematurity.
Pediatr Pulmonol
October 2024
Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus University Medical Center- Sophia Children's Hospital, Rotterdam, the Netherlands.
Article Synopsis
- - Approximately 10% of children globally are born preterm, which often leads to respiratory issues and hospitalizations.
- - Preterm birth results in lower lung function that can persist into adulthood, affecting even children born moderate to late preterm.
- - To enhance respiratory health in preterm-born individuals, a diverse, phenotype-based approach to management is essential due to the varying nature of lung disease associated with prematurity.
Evolving treatment for prematurity-associated lung disease.
Transl Pediatr
January 2024
Department of Child Health, School of Medicine, Cardiff University, Cardiff, UK.
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