An unprecedented cascade strategy consisting of polarity reversal, normal electron-demand Diels-Alder cycloaddition and skeletal remodeling was developed to construct novel pyridine-fused nitrones in up to 82% yield. The key to the success was the umpolung process, which transformed the electron-deficient 3-nitropyridinium ring into a reactive, π-extended cyclic nitroalkene, serving as a rarely reported hetero-diene to participate in normal Diels-Alder cycloadditions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d2cc00155a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Astrocyte-conditional knockout of MOB2 inhibits the phenotypic conversion of reactive astrocytes from A1 to A2 following spinal cord injury in mice.
Int J Biol Macromol
January 2025
Department of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, People's Republic of China. Electronic address:
After spinal cord injury (SCI), reactive astrocytes in the injured area are triggered after spinal cord injury (SCI) and to polarize into A1 astrocytes with a proinflammatory phenotype or A2 astrocytes with an anti-inflammatory phenotype. Monopolar spindle binder 2 (MOB2) induces astrocyte stellation, maintains cell homeostasis, and promotes neurite outgrowth; however, its role in the phenotypic transformation of reactive astrocytes remains unclear. Here, we confirmed for the first time that MOB2 is associated with A1/A2 phenotypic switching in reactive astrocytes following SCI in mice.
View Article and Find Full Text PDFSpleen tyrosine kinase aggravates intestinal inflammation through regulating inflammatory responses of macrophage in ulcerative colitis.
Int Immunopharmacol
January 2025
Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Department of Gastroenterology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining 272000, China. Electronic address:
Background: Ulcerative colitis (UC) is a persistent chronic, non-specific inflammatory disease, and macrophages play a crucial role in its pathogenesis. Spleen tyrosine kinase (Syk) is strongly associated with the pathogenesis of several inflammatory diseases. However, the role of Syk in the pathogenesis of UC is still obscure.
View Article and Find Full Text PDFPhotoluminescence and Photocurrent from InGaN/GaN Diodes with Quantum Wells of Different Widths and Polarities.
Nanomaterials (Basel)
January 2025
Institute of High Pressure Physics, Polish Academy of Sciences, Sokołowska 29/37, 01-142 Warsaw, Poland.
We compare the optical properties of four diode samples differing by built-in field direction and width of the InGaN quantum well in the active layer: two diodes with standard layer sequences and 2.6 and 15 nm well widths and two diodes with inverted layer ordering (due to the tunnel junction grown before the structure) also with 2.6 and 15 nm widths.
View Article and Find Full Text PDFTwo-Dimensional Ferroelectric Materials: From Prediction to Applications.
Nanomaterials (Basel)
January 2025
Department of Mechanical Engineering, Hong Kong Polytechnic University, Hong Kong 999077, China.
Ferroelectric materials hold immense potential for diverse applications in sensors, actuators, memory storage, and microelectronics. The discovery of two-dimensional (2D) ferroelectrics, particularly ultrathin compounds with stable crystal structure and room-temperature ferroelectricity, has led to significant advancements in the field. However, challenges such as depolarization effects, low Curie temperature, and high energy barriers for polarization reversal remain in the development of 2D ferroelectrics with high performance.
View Article and Find Full Text PDFSpacer Designs for Improved Hydrodynamics and Filtration Efficiency in Sea Water Reverse Osmosis.
Membranes (Basel)
January 2025
Environmental Science and Engineering Program, Division of Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
Reverse osmosis (RO) filtration performance is heavily influenced by the design of the feed spacer. Spacer design impacts hydrodynamic patterns within the system, affecting water production and concentration polarization. Two spacer designs, namely pillar (P) and standard (S), were investigated to improve the performance of a commercially available spacer design (C) in the RO process.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!