AI Article Synopsis
- A 9-year-old boy with leukemia had an unusual reaction to high doses of methotrexate, experiencing hypersensitivity and acral erythema, which are rare side effects.
- The symptoms were assessed for severity, and strategies like slowing the infusion rate and providing premedication allowed the boy to continue his treatment.
- Acral erythema improved with basic supportive care, and it was concluded that such reactions can happen even in the first treatment course without needing to change the overall chemotherapy plan unless absolutely necessary.
Article Abstract
A 9-year-old boy with acute lymphoblastic leukemia experienced a hypersensitivity reaction (HSR) and acral erythema upon receiving high-dose methotrexate (HDMTX). Both HSR and acral erythema are uncommon adverse events of MTX therapy, and MTX has not been reported to cause HSRs in specific ethnic groups. We assessed the severity of each symptom and were successful in managing these adverse events for continuing subsequent HDMTX therapies. HSR appeared during the first and second HDMTX courses. Acral erythema occurred after the second and fourth courses. Desensitization by reducing the infusion rate and premedication allowed the continuation of HDMTX. Acral erythema improved with supportive care without dose reduction or interval lengthening. HSRs to MTX should be considered even during the first course. MTX-induced acral erythema is a self-limited reaction; therefore, the chemotherapeutic regimen should not be modified unless necessary.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.5414/CP204143 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Erythema multiforme.
EClinicalMedicine
November 2024
GrIDIST (Groupe Infectiologie et Infections Sexuellement Transmissibles) Working Group of the French Society of Dermatology, France.
Unlabelled: Erythema multiforme is an inflammatory skin and mucosal disease mainly related to infectious agents such as Herpes simplex virus, , though it can also be "idiopathic". The characteristic skin lesions are typical or atypical acral raised target lesions. The oral mucosa can be affected, alone or in combination with other mucosal/cutaneous sites, sometimes causing extreme pain, severely impacting food intake, and warranting hospitalization.
View Article and Find Full Text PDFUrticaria multiforme in school age: A case report.
Arch Argent Pediatr
September 2024
Department of Pediatrics, Hospital General de Agudos Dr. J. A. Fernández, City of Buenos Aires, Argentina.
Article Synopsis
- - Urticaria multiforme is a benign allergic skin reaction that commonly appears in children aged 4 months to 4 years, characterized by annular and polycyclic wheals with a purple center.
- - The condition is self-limited and often accompanied by symptoms such as acral edema and fever, making it essential for pediatricians to recognize and diagnose it based on clinical symptoms.
- - Important differential diagnoses include acute urticaria, urticarial vasculitis, and erythema multiforme, with the aim of training pediatricians on proper identification and reassurance for parents.
Fractional CO2 Laser Versus Microneedling Combined with Narrowband Ultraviolet and Topical Steroid for Treating Non-Segmental Vitiligo in Treatment-Resistant Localizations: A Comparative Randomized Clinical Trial Study.
J Lasers Med Sci
August 2024
Skin and Stem Cell Research Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Vitiligo poses a significant challenge, particularly in treatment-resistant areas such as acral regions. This study aimed to evaluate the effectiveness and safety of combining fractional CO2 laser and microneedling with conventional therapies for non-segmental vitiligo in resistant areas. A randomized clinical trial with a paired design was conducted on 84 individuals with non-segmental vitiligo and treatment-resistant lesions.
View Article and Find Full Text PDFBilateral Blistering Rash Following Gastric Bypass Procedure and Mushroom Soup Diet: Hepatitis C Virus-Seronegative Necrolytic Acral Erythema.
Cureus
July 2024
Department of Dermatology, James A. Haley Veterans' Hospital, Tampa, USA.
Article Synopsis
- * A case study discusses a 66-year-old patient who, after having gastric bypass surgery, developed NAE due to a poor diet limited to just mushroom soup for three months, without any history of hepatitis C.
- * The patient was treated with zinc replacement after other treatments failed, and showed significant improvement at follow-up, highlighting how NAE can occur from nutritional deficiencies outside of known viral infections like HCV.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!