AI Article Synopsis
- - Six new sesquiterpenoids (ainslides A-F) were identified and isolated from the plant Ainsliaea pertyoides, along with eight previously known compounds.
- - The structures of these compounds were determined using advanced techniques like NMR, mass spectrometry, UV, IR spectroscopy, and X-ray diffraction.
- - The anti-inflammatory potential of these compounds was tested, revealing that several, particularly compounds 3 and 7-13, effectively inhibit the NLRP3 inflammasome with IC values ranging from 1.80 to 4.33 μM.
Article Abstract
Six new sesquiterpenoids, named as ainslides A-F (1-6), including one carotene-type sesquiterpene (1), one eudesmane (2), four guaianolides (3-6), together with eight known sesquiterpenoids (7-14), were purified from the whole plants of Ainsliaea pertyoides. The structures of these sesquiterpenoids were characterized based on spectroscopic methods including 1D and 2D NMR, HR-ESI-MS, UV, and IR spectra, together with ECD calculations and X-ray diffraction experiments. The anti-inflammatory activity of all the isolated compounds was screened and compounds 3 and 7-13 exhibited NLRP3-inflammasome inhibitory activity with IC values of 1.80-4.33 μM.
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| http://dx.doi.org/10.1002/cbdv.202200135 | DOI Listing |
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Ainslides A-F, Six Sesquiterpenoids Isolated from Ainsliaea pertyoides and Their NLRP3-Inflammasome Inhibitory Activity.
Chem Biodivers
May 2022
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China.
Article Synopsis
- - Six new sesquiterpenoids (ainslides A-F) were identified and isolated from the plant Ainsliaea pertyoides, along with eight previously known compounds.
- - The structures of these compounds were determined using advanced techniques like NMR, mass spectrometry, UV, IR spectroscopy, and X-ray diffraction.
- - The anti-inflammatory potential of these compounds was tested, revealing that several, particularly compounds 3 and 7-13, effectively inhibit the NLRP3 inflammasome with IC values ranging from 1.80 to 4.33 μM.
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