Unlabelled: Selecting a quantitative measure to guide decision making in single-case experimental designs (SCEDs) is complicated. Many measures exist and all have been rightly criticized. The two general classes of measure are overlap-based (e.g., percentage nonoverlapping data) and distance-based (e.g., Cohen's ). We compare several measures from each category for Type I error rate and power across a range of designs using equal numbers of observations (i.e., 3-10) in each phase. Results showed that Tau and the distance-based measures (i.e., RD and ) provided the highest decision accuracies. Other overlap-based measures (e.g., PND, dual-criterion method) did not perform as well. It is recommended that Tau be used to guide decision making about the presence/absence of a treatment effect, and RD or be used to quantify the magnitude of the treatment effect.
Supplementary Information: The online version contains supplementary material available at 10.1007/s40614-021-00317-8.
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http://dx.doi.org/10.1007/s40614-021-00317-8 | DOI Listing |
Talanta
December 2024
Analytical Chemistry Division, Chemistry Department, Lomonosov Moscow State University, 119234, Moscow, Russia. Electronic address:
Novel and simple spectrophotometric and distance based procedures for thiols (L-cysteine, N-acetylcysteine, and glutathione) determination in biological fluids and pharmaceuticals have been proposed based on their inhibitory action on the oxidation of catechol in the presence of Agaricus bisporus crude extract (ABE). The influence of L-glycine, L-alanine, L-proline, L-methionine, L-cystine, ascorbic acid, uric acid, and bilirubin on the thiol determination has been investigated. Uric acid, bilirubin, L-cystine (oxidized thiol), and L-amino acids do not interfere with the determination.
View Article and Find Full Text PDFBiosensors (Basel)
November 2024
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
Point-of-care (POC) immunoassays have become convincing alternatives to traditional immunosensing methods for the sensitive and real-time detection of targets. Immunoassays based on gas-generating reactions were recently developed and have been used in various fields due to their advantages, such as rapid measurement, direct reading, simple operation, and low cost. Enzymes or nanoparticles modified with antibodies can effectively catalyze gas-generating reactions and convert immunorecognition events into gas pressure signals, which can be easily recorded by multifunctional portable devices.
View Article and Find Full Text PDFNat Hum Behav
December 2024
Institute for Data, Systems, and Society, Massachusetts Institute of Technology, Cambridge, MA, USA.
Disruptions, such as closures of businesses during pandemics, not only affect businesses and amenities directly but also influence how people move, spreading the impact to other businesses and increasing the overall economic shock. However, it is unclear how much businesses depend on each other during disruptions. Leveraging human mobility data and same-day visits in five US cities, we quantify dependencies between points of interest encompassing businesses, stores and amenities.
View Article and Find Full Text PDFBMC Med Res Methodol
December 2024
Centre for Quantitative Medicine, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.
Background: Traditional clustering techniques are typically restricted to either continuous or categorical variables. However, most real-world clinical data are mixed type. This study aims to introduce a clustering technique specifically designed for datasets containing both continuous and categorical variables to offer better clustering compatibility, adaptability, and interpretability than other mixed type techniques.
View Article and Find Full Text PDFPLoS One
December 2024
College of Management and Engineering, Capital University of Economics and Business, Beijing, China.
The Internet of Vehicles (IoV) makes it possible to transmit information in real time between vehicles, providing a modern approach for autonomous driving, traffic safety, and other applications. Roadside units (RSUs) contribute to the enhancement of IoV's reliability and transmission efficiency, while mitigating the impact of low IoV penetration. The objective of RSU deployment optimization is to minimize the total cost with the premise of ensuring IoV reliability.
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