AI Article Synopsis
- The study focused on formulating a stable multiple emulsion (MNF) that incorporates niacinamide and ferulic acid, aiming to enhance skin permeation of these actives.
- Both the compounds were tested for their antioxidant properties and the formulated emulsions were subjected to stability testing over three months, checking aspects like color, pH, and droplet size.
- Results indicated that MNF is not only stable under various conditions but also effectively improves skin conditions by reducing melanin and sebum while increasing hydration and elasticity.
Article Abstract
Objective: Multiple emulsions have the ability to incorporate both lipophilic and hydrophilic actives in the same preparation and facilitate permeation of active ingredients through skin. The current study was aimed at formulating niacinamide/ferulic acid-loaded stable multiple emulsion (MNF) and its / characterization as a cosmeceutical product.
Methods: Both the compounds were evaluated for their radical scavenging potential by the DPPH method and FTIR analysis. Then, placebo and active formulations were prepared using a double emulsification method and were investigated for stability testing (changes in color, odor, and liquefaction on centrifugation, pH, and globule size) for a period of three months. Afterwards, MNF was investigated for sun protection factor, rheological studies, entrapment efficiency, zeta potential, zeta size, and permeation. Moreover, after ensuring the hypoallergenicity and safety, it was also checked for its cosmeceutical effects on human skin using noninvasive biophysical probes in comparison with placebo.
Results: Results demonstrated that MNF showed a non-Newtonian behavior rheologically and both MNF and placebo were stable at different storage conditions. Entrapment efficiency, zeta potential, and zeta size were 93.3%, -5.88 mV, and 0.173 m, respectively. Moreover, melanin, sebum, and skin erythema were significantly reduced while skin elasticity and hydration were improved.
Conclusion: It is evident that niacinamide and ferulic acid can be successfully incorporated in a stable multiple emulsion which has potent cosmeceutical effects on human skin.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947885 | PMC |
| http://dx.doi.org/10.1155/2022/1725053 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Quality by Design (QbD)-Driven Development and Optimization of Tacrolimus-Loaded Microemulsion for the Treatment of Skin Inflammation.
Pharmaceutics
November 2024
School of Pharmacy, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA.
Skin inflammation represents a hallmark of many skin conditions, from psoriasis to eczema. Here, we present a novel microemulsion formulation for delivering a low dose of potent immunosuppressant, tacrolimus, to the skin for local inflammation control. The efficacy of topically delivered tacrolimus in controlling skin inflammation can be enhanced by packaging it into microemulsions.
View Article and Find Full Text PDFUltrasonic combined pH shifting strategy for improving the stability of emulsion stabilized by yeast proteins: Focused on solubility, protein structure, interface properties.
Int J Biol Macromol
January 2025
College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China. Electronic address:
In this study, the improvement mechanism of yeast proteins (YPs) with the ultrasonic and pH shifting treatment on the emulsion stability was investigated through the solubility, protein structure and interface behavior of YPs. Compared with only pH shifting or ultrasound treatment, the solubility of YPs with the combined treatment of ultrasonic and pH shifting was increased significantly. The soluble protein content of pH-U400 reached 85.
View Article and Find Full Text PDFBridged emulsion gels from polymer-nanoparticle enabling large-amount biomedical encapsulation and functionalization.
Nat Commun
December 2024
Key Laboratory of Materials Chemistry for Energy Conversion and Storage of Ministry of Education (HUST), School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan, 430074, China.
Large-amount encapsulation and subsequent expressing are common characteristics for many biomedical applications, such as cosmetic creams and medical ointments. Emulsion gels can accomplish that, but often undergo exclusive, complex, multiple synthesis steps, showing extremely laborious and non-universal. The method here is simple via precisely interfacial engineering in homogenizing a nanoparticle aqueous dispersion and a polymer oil solution, gaining interfacial 45° three-phase-contact-angle for the nanoparticle that can bridge across oil emulsions' interfaces and ultimately form interconnected macroscopic networks.
View Article and Find Full Text PDFUntargeted metabolomics analysis of glycerophospholipid metabolism in very low birth weight infants administered multiple oil lipid emulsions.
BMC Pediatr
December 2024
Department of Intensive Care Unit, Hangzhou Women's Hospital, Hangzhou, 310016, Zhejiang, China.
Background: To compare the impact of two different lipid emulsions, specifically a soybean oil-based emulsion and a multiple oil emulsion (soybean oil, medium-chain triglycerides, olive oil, and fish oil, SMOF), on serum metabolites of very low birth weight (VLBW) infants using untargeted metabolomics analysis.
Methods: A comparative study was conducted on 25 VLBW infants hospitalized in neonatal intensive care units (NICU) of Hangzhou Women's Hospital in 2023. The infants were divided into the SMOF group (13 cases) and the soybean oil group (12 cases) based on the type of lipid emulsion used during parenteral nutrition.
The use of hydrogel microspheres as cell and drug delivery carriers for bone, cartilage, and soft tissue regeneration.
Biomater Transl
September 2024
Biomedical Engineering Program, Westlake University, Hangzhou, Zhejiang Province, China.
Bone, cartilage, and soft tissue regeneration is a complex process involving many cellular activities across various cell types. Autografts remain the "gold standard" for the regeneration of these tissues. However, the use of autografts is associated with many disadvantages, including donor scarcity, the requirement of multiple surgeries, and the risk of infection.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!