AI Article Synopsis
- Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare but challenging condition associated with cancer, difficult to diagnose before death due to quick onset of symptoms.
- The case described involved a patient with lymphedema who developed PTTM, presenting with pulmonary hypertension and ultimately passing away after 9 days in the hospital without a definitive diagnosis from initial tests.
- An autopsy revealed tumor embolisms in the lungs and cell proliferation, but the primary source of the cancer was not found, marking this as the first reported instance of PTTM linked to lymphedema.
Article Abstract
Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare manifestation of malignancy. The antemortem diagnosis is difficult, since patients present with rapidly progressive symptoms. We recently observed a case of PTTM following lymphedema of the lower extremities. We did not reach a diagnosis, even after performing BAL and TBLB. The patient manifested pulmonary hypertension and died on the 9th day of admission. Autopsy revealed a tumor embolism in the pulmonary arterioles accompanied by fibrocellular epithelial cell proliferation, but the primary organ was not identified. To our knowledge, this is the first reported case of PTTM with lymphedema.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941268 | PMC |
| http://dx.doi.org/10.1016/j.rmcr.2022.101631 | DOI Listing |
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