Objective: The aim of this study was to determine the correlation between neutrophil-to-lymphocyte ratio (NLR) and various tumor parameters assessed by pretreatment magnetic resonance imaging (MRI) and to evaluate their prognostic significance for cervical carcinoma treated with radiotherapy (RT).
Methods: The study enrolled 78 patients with biopsy-proven squamous cell carcinoma (SCC) of primary cervical cancer (clinically staged IB2 to IVA) who were treated in the Department of Clinical Oncology of the University of Hong Kong-Shenzhen Hospital between August 2015 and May 2019. A retrospective analysis of patients with SCC was performed. Firstly, we investigated the correlations between NLR and MRI parameters. Then, univariate and multivariate analyses were performed to identify the prognostic factors for overall survival (OS) and progression-free survival (PFS). Kaplan-Meier curves were constructed for OS and PFS.
Results: Higher NLR showed significant association with larger tumor diameter and parametrial invasion assessed by pretreatment MRI. Univariate analysis indicated that uterine body invasion, parametrial invasion, and NLR were associated with prognosis of cervical cancer. Multivariable analyses demonstrated that parametrial invasion and NLR higher than the cutoff were independently associated with shorter OS and PFS, whereas uterine body invasion showed a significantly unfavorable influence on OS but showed no significant effect on PFS. Using the three risk factors of NLR above cutoff, parametrial invasion, and uterine body invasion, patients were divided into three subgroups. The three-year OS rates of patients with zero risk factors, one risk factor, and two or three of these factors were 96%, 91%, and 42%, respectively ( < 0.001), showing a downward trend.
Conclusions: Uterine body invasion, parametrial invasion, and NLR were significant prognostic factors for patients with cervical carcinoma treated with RT. These results may supplement FIGO staging to improve prognostic assessment of patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956400 | PMC |
| http://dx.doi.org/10.1155/2022/3409487 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Limited diagnostic performance of imaging evaluation for staging in gastric-type endocervical adenocarcinoma: a multi-center study.
Jpn J Radiol
December 2024
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Shogoinkawahara-Cho 54, Sakyo-Ku, Kyoto, 606-8507, Japan.
Purpose: The purposes of the study are to assess the diagnostic performance of preoperative imaging for staging factors in gastric-type endocervical adenocarcinoma (GEA) and to compare the performance for GEA with that of usual-type endocervical adenocarcinoma (UEA) among patients preoperatively deemed locally early stage (DLES) (< T2b without distant metastasis).
Materials And Methods: For this multi-center retrospective study, 58 patients were enrolled. All had undergone MRI with or without CT and FDG PET-CT preoperatively and had been pathologically diagnosed with GEA at five institutions.
The value of amide proton transfer imaging in predicting parametrial invasion and lymph-vascular space invasion of cervical cancer.
Magn Reson Imaging
February 2025
Department of Radiology, Tongren People's Hospital, Tongren, Guizhou Province 554300, China.
Objective: To explore the value of amide proton transfer (APT) imaging in assessing parametrial invasion (PMI) and lymph-vascular space invasion (LVSI) of cervical cancer.
Materials And Methods: We retrospectively analyzed the clinical and imaging data of cervical cancer patients diagnosed pathologically at our hospital from January 2021 to June 2024. All patients underwent routine magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and APT imaging before treatment.
Association Between Adenomyosis and Cervical Cancer: A Retrospective Cohort Study.
J Invest Surg
December 2024
Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Article Synopsis
- - The study aimed to investigate the clinicopathological features and survival outcomes of cervical cancer (CC) patients, comparing those with adenomyosis to those without to see how adenomyosis affects CC characteristics.
- - Researchers analyzed data from 991 CC patients with adenomyosis and 3964 without, focusing on various tumor characteristics and using statistical tests to assess the differences.
- - Findings showed that CC patients with adenomyosis had less aggressive tumor features like deep stromal invasion and vaginal infiltration; however, adenomyosis did not significantly influence survival outcomes for CC patients.
Magnetic Resonance Imaging Evaluation of Carcinoma of the Cervix With Histopathological Correlation in a Tertiary Care Center: Emphasizing the Rise of Adenocarcinoma in the Indian Context.
Cureus
October 2024
Radiodiagnosis, Department of Radiology, Karpaga Vinayaga Institute of Medical Sciences and Research Centre, Maduranthakam, IND.
Background and objectives Adenocarcinoma is increasingly being described in the histological profile of cervical cancer, which is a significant alteration in the disease's profile. This study, which highlights the rising incidence of adenocarcinoma in India, attempts to evaluate the relationship between magnetic resonance imaging (MRI) and histological findings in cervical cancer. The goal is to assess the utility of MRI in tumor staging and its consequences for the management of this evolving histological trend.
View Article and Find Full Text PDFEndocervical Adenocarcinoma With Micropapillary Component, a Distinct Histological Subtype Associated With Aggressive Behavior and Poor Prognosis: A Clinicopathologic Study of 10 Patients.
Int J Surg Pathol
November 2024
Department of Pathology, Zhejiang University School of Medicine Women's Hospital, Hangzhou, Zhejiang Province, China.
Endocervical adenocarcinoma (ECA) with a micropapillary component is considered to be associated with aggressive behavior and poor prognosis. So far, only limited studies investigated this histological subtype of ECA in the literature. In this study, we present a clinicopathological analysis of 10 such tumors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!