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Pulmonary fibrosis as the sole manifestation of anti-Ku antibody positivity in the absence of myositis: A case report.
Respir Med Case Rep
January 2025
Department of Rheumatology of Lucania - UOSD of Rheumatology, "Madonna delle Grazie" Hospital, Matera, Italy.
Background: Anti-Ku antibodies are autoantibodies directed against the Ku protein complex involved in DNA repair. They are typically associated with overlap syndromes featuring polymyositis and systemic sclerosis. Isolated pulmonary involvement without myositis is exceedingly rare.
View Article and Find Full Text PDFIntegrating e-learning into the educational framework for undergraduate medical training: a Nigerian survey on trainers´ perception and readiness.
Pan Afr Med J
October 2024
Department of Paediatrics, Olabisi Onabanjo University, Ago-Iwoye, Ogun State, Nigeria.
Introduction: given the significant disruption in educational activities during the COVID-19 pandemic and the uncertainties about the post-pandemic future, coupled with increasing demand for the healthcare workforce, e-learning may bridge the gap in training medical students. It was imperative to survey the perception and readiness of the trainers on the use of e-learning for undergraduate medical training in Nigeria.
Methods: this cross-sectional study was conducted among teachers of medical students in Nigeria.
estiMAge: development of a DNA methylation clock to estimate the methylation age of single cells.
Bioinform Adv
January 2025
Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, D-69120 Heidelberg, Germany.
Motivation: Since their introduction about 10 years ago, methylation clocks have provided broad insights into the biological age of different species, tissues, and in the context of several diseases or aging. However, their application to single-cell methylation data remains a major challenge, because of the inherent sparsity of such data, as many CpG sites are not covered. A methylation clock applicable on single-cell level could help to further disentangle the processes that drive the ticking of epigenetic clocks.
View Article and Find Full Text PDFSquamous Cell Carcinoma Originating From Mature Cystic Teratoma of the Ovary Diagnosed 10 Years After Initial Tumor Detection: A Case Report.
Cureus
December 2024
Obstetrics and Gynecology, Marunouchi Hospital, Matsumoto, JPN.
Malignant transformation is a rare complication of ovarian mature cystic teratoma that occurs in 1-3% of cases. We herein report a case of squamous cell carcinoma originating from mature cystic teratoma of the ovary diagnosed 10 years after initial tumor detection. A 69-year-old woman presented to the Department of Internal Medicine with a seven-month history of abdominal fullness.
View Article and Find Full Text PDFRegulatory Immune Cell-derived Exosomes: Modes of Action and Therapeutic Potential in Transplantation.
Transplantation
January 2025
Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh PA.
Reduced dependence on antirejection agents, improved long-term allograft survival, and induction of operational tolerance remain major unmet needs in organ transplantation due to the limitations of current immunosuppressive therapies. To address this challenge, investigators are exploring the therapeutic potential of adoptively transferred host- or donor-derived regulatory immune cells. Extracellular vesicles of endosomal origin (exosomes) secreted by these cells seem to be important contributors to their immunoregulatory properties.
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