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Nanoparticle Biomolecular Corona-Based Enrichment of Plasma Glycoproteins for N-Glycan Profiling and Application in Biomarker Discovery. | LitMetric

AI Article Synopsis

  • Biomolecular corona formation is important in nanomedicine and could help with disease diagnosis, specifically through analyzing proteins around nanoparticles.
  • This study integrates personalized protein corona and N-glycosylation profiling to enhance the discovery of biomarkers in human plasma.
  • Using silica nanoparticles, researchers enriched plasma fibrinogen to identify unique glycan profiles, which showed promise in distinguishing lung cancer patients from healthy individuals in preliminary tests.

Article Abstract

Biomolecular corona formation has emerged as a recurring and important phenomenon in nanomedicine that has been investigated for potential applications in disease diagnosis. In this study, we have combined the "personalized protein corona" with the N-glycosylation profiling that has recently gained considerable interest in human plasma biomarker discovery as a powerful early warning diagnostic and patient stratification tool. We envisioned that the protein corona formation could be exploited as an enrichment step that is critically important in both proteomic and proteoglycomic workflows. By using silica nanoparticles, plasma fibrinogen was enriched to a level in which its proteomic and glycomic "fingerprints" could be traced with confidence. Despite being a more simplified glycan profile compared to full plasma, the corona glycan profile revealed a fibrinogen-derived glycan peak that was found to potentially distinguish lung cancer patients from controls in a pilot study.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047655PMC
http://dx.doi.org/10.1021/acsnano.1c09564DOI Listing

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