Clinical Analysis of Bloodstream Infection of in Patients with Pancreatic Cancer from 2011 to 2019.

Background: Pancreatic cancer patients were particularly predisposed to develop bloodstream infection (BSI); however, little information is currently available. We set out to find BSI's risk factors in pancreatic cancer to provide valuable experience.

Methods: We retrospectively analyzed the clinical data of pancreatic cancer patients (31 cases with BSI and 93 cases without BSI) by a case-control study. SPSS 17.0 was adopted to perform univariate and multivariate analyses. Bacterial resistance analysis was performed by Whonet 5.6.

Results: Hospitalization days ≥7 days, number of admissions ≥2 times, surgery, chemotherapy, the type of antibiotics used ≥2 species, albumin<40.0 g/L, and prealbumin < 0.2 g/L were the potential risk factors for pancreatic cancer patients with BSI ( < 0.1). Multivariate logistic regression showed hospitalization days ≥7 days (OR = 11.196, 95% CI = 0.024-0.333, < 0.001), surgery (OR = 32.053, 95% CI = 0.007-0.137, < 0.001), and chemotherapy (OR = 6.174, 95% CI = 0.038-0.688, =0.014) were the independent risk factors for BSI of pancreatic cancer patients. resistant to carbapenems was rare; they were susceptible to cephamycin and piperacillin/tazobactam. The 90-day mortality rate of the infected group was significantly higher than the control group (41.9% versus 8.6%, < 0.001).

Conclusions: Hospitalization days ≥7 days, surgery, and chemotherapy are the independent risk factors for BSI of pancreatic cancer patients, which allows us to identify patients at potential risk and perform preventive treatment in time.