Mortality Risk Factors for Patients With Sepsis-Induced Blood Pressure Drop: A Single-Center Retrospective Study.

Introduction: Sepsis is a life-threatening illness caused by the body's response to uncontrolled infection. Different studies have been conducted to identify risk factors associated with the diagnosis of sepsis and mortality, but there has been considerably less focus on mortality due to sepsis-induced blood pressure. The current study was conducted to determine the incidence of mortality within 30 days among patients with sepsis-induced blood pressure drop and its risk factors.

Methodology: It was a retrospective study conducted at the Pakistan Navy Station (PNS) Shifa Hospital, Karachi, Pakistan. Data of all patients aged 18 years or more who visited PNS Shifa Hospital and were diagnosed with sepsis and blood pressure reduction from November 2019 to October 2021 were extracted from Hospital Management Information System (HMIS) and retrospectively analyzed Results: All variables significantly associated with 30-days mortality in multivariable logistic regression analysis, including disturbance of consciousness, cardiac insufficiency, respiratory failure, diabetes mellitus, creatinine level, and aspartate aminotransferase (AST) level, were risk factors for mortality in patients with the sepsis-induced drop in blood pressure (p-value<0.05).

Conclusion: Identifying these risk factors is important as it will help clinicians identify patients who are at high risk of mortality at an early stage. Through early identification, interventions can be done to reduce the incidence of in-hospital mortality among sepsis patients.