Background: The geometry of leaflets plays a significant role in prosthetic valves' (PVs) performance. Typically, natural aortic valves have three unequal leaflets, which differ in size. The present study aims to design an asymmetric tri-leaflet polymeric valve with one large and two small leaflets based on commissure lengths and leaflet eccentricities.
Methods: Eccentricity was related to commissure lengths based on the deformation of the free margins for the fully-opened state of leaflets. The polystyrene-block-polyethylene-polypropylene-block-polystyrene polymer characterized the material properties of the leaflets. The Finite Element Method (FEM) was used to evaluate performance parameters, including maximum geometric orifice area (GOA), average GOA, maximum von Mises stress, and leaflet's coaptation surface area (CSA).
Results: Asymmetric valves with no eccentricity provided a low level of GOA because the asymmetric form of small leaflets caused them to close faster than the large leaflet, leading to a sudden drop in the GOA during systole. As the radial curve tends towards a straight line, an undesirable coaptation occurs, and peak stress increases despite higher GOAs. A new radial curve consisting of two straight lines connected by an arc that provided 25.64 mm coaptation surface area (CAS) and 117.54 mm average GOA, was proposed to improve coaptation and GOA.
Conclusion: The radial curve of leaflets affects the valve's performance more than other geometric parameters. The combination of straight lines and arcs for radial curves was selected as the reference model for asymmetric valves with one large and two small leaflets.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.compbiomed.2022.105440 | DOI Listing |
MethodsX
June 2025
Department of Computer Science, School of Computing, Amrita Vishwa Vidyapeetham, Mysuru, India.
Real-time plant species detection plays an important role in fields ranging from medicine to biodiversity conservation. Images captured under unconstrained environments, scale variations, different lighting conditions, leaf orientation, complicated backdrops, and leaflet structure make plant species recognition rigorous and time-consuming. Our study addresses this challenge by introducing three pioneering hybrid models, seamlessly integrating the strengths of convolution neural networks.
View Article and Find Full Text PDFVet Radiol Ultrasound
January 2025
AniCura Istituto Veterinario Novara, Monticello, Italy.
With the advancement in imaging technology, ECG-gated cardiac multidetector computed tomography (MDCT) has emerged as a tool for the anatomic evaluation of the pulmonary valve and right ventricular outflow tract (RVOT) in human medicine. Currently, the evaluation of the pulmonary valve relies primarily on echocardiographic examination. However, the bi-dimensional nature of this technique and the location/orientation of the pulmonary valve in the thoracic cavity can pose challenges.
View Article and Find Full Text PDFMolecules
December 2024
Coimbra Chemistry Center, Institute of Molecular Sciences (CQC-IMS), University of Coimbra, 3004-535 Coimbra, Portugal.
The membrane dipole potential that arises from the interfacial water and constitutive dipolar groups of lipid molecules modulates the interaction of amphiphiles and proteins with membranes. Consequently, its determination for lipid mixtures resembling the existing diversity in biological membranes is very relevant. In this work, the dipole potentials of monolayers, formed at the air-water interface, from pure or mixed lipids (1-palmitoyl-2-oleoyl--glycero-3-phosphocholine (POPC), 1-palmitoyl-2-oleoyl--glycero-3-phosphoethanolamine (POPE), 1-palmitoyl-2-oleoyl--glycero-3-phosphatidyserine (POPS), sphingomyelin (SpM) and cholesterol) were measured and correlated with the mean area per lipid.
View Article and Find Full Text PDFJ Comput Assist Tomogr
November 2024
From the Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD.
Purpose: Cardiac computed tomography angiography (CCTA) has significantly advanced the visualization of cardiac structures, particularly valves. We assessed the diagnostic performance of CCTA in diagnosing the most common disorders affecting the aortic valves requiring surgery-papillary fibroelastoma, infective endocarditis, and degeneration.
Methods: This retrospective study included patients who underwent aortic valve resection between 2016 and 2023 and had a preceding CCTA.
Front Vet Sci
December 2024
Department of Cardiology, Uenonomori Animal Hospital, Tokyo, Japan.
Objectives: Surgical options for mitral valve repair in dogs are unstandardized and influenced by various factors. This study describes a four-point surgical technique (MI-4) to reduce mitral regurgitation and provides data from a study of dogs with 12 months of follow up.
Methods: Twenty-five dogs with stages C or D mitral insufficiency were treated by one of two surgeons using the MI-4 procedure at Ueno no Mori Animal Hospital between October 2021 and May 2023.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!