AI Article Synopsis
- Interest in pyrrole and pyrrolopyrimidine derivatives has grown due to their significant biological activities, including anti-cancer, anti-microbial, and anti-viral effects, particularly against COVID-19.
- Scientists are eager to explore more of these compounds because the pyrrole structure plays a crucial role in many pharmaceuticals.
- This article reviews various synthetic methods for creating pyrrole and its fused compounds, especially pyrrolopyrimidine, while highlighting their medicinal benefits from 2017 to 2021.
Article Abstract
In the last several decades, interest in pyrrole and pyrrolopyrimidine derivatives has increased owing to their biological importance, such as anti-tumor, anti-microbial, anti-inflammatory, anti-diabetic, anti-histaminic, anti-malarial, anti-Parkinson, antioxidant and anti-viral effects, specially recently against COVID-19. These tremendous biological features have motivated scientists to discover more pyrrole and fused pyrrole derivatives, owing to the great importance of the pyrrole nucleus as a pharmacophore in many drugs, and motivated us to present this article, highlighting on the different synthetic pathways of pyrrole and its fused compounds, specially pyrrolopyrimidine, as well as their medicinal value from 2017 till 2021.
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| http://dx.doi.org/10.2174/1573406418666220325141952 | DOI Listing |
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