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The Ivermectin Related Compound Moxidectin Can Target Apicomplexan Importin α and Limit Growth of Malarial Parasites.
Cells
January 2025
Nuclear Signaling Laboratory, Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Signal-dependent transport into and out of the nucleus mediated by members of the importin (IMP) superfamily is crucial for eukaryotic function, with inhibitors targeting IMPα being of key interest as anti-infectious agents, including against the apicomplexan species and , causative agents of malaria and toxoplasmosis, respectively. We recently showed that the FDA-approved macrocyclic lactone ivermectin, as well as several other different small molecule inhibitors, can specifically bind to and inhibit and IMPα functions, as well as limit parasite growth. Here we focus on the FDA-approved antiparasitic moxidectin, a structural analogue of ivermectin, for its IMPα-targeting and anti-apicomplexan properties for the first time.
View Article and Find Full Text PDFTreatment of cattle with ivermectin and its effect on dung degradation and larval abundance in a tropical savanna setting.
One Health
June 2025
Department of Entomology, Virgina Polytechnic Institute & State University, Blacksburg, VA 24061, USA.
When ingested as part of a blood meal, the antiparasitic drug ivermectin kills mosquitoes, making it a candidate for mass drug administration (MDA) in humans and livestock to reduce malaria transmission. When administered to livestock, most ivermectin is excreted unmetabolized in the dung within 5 days post administration. Presence of ivermectin, has been shown to adversely affect dung colonizers and dung degradation in temperate settings; however, those findings may not apply to, tropical environment, where ivermectin MDA against malaria would occur.
View Article and Find Full Text PDFRegional action needed to halt antimalarial drug resistance in Africa.
Lancet
January 2025
Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok 10400, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK; WorldWide Antimalarial Resistance Network, Oxford, UK. Electronic address:
Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia.
Sci Rep
November 2024
The Sumba Foundation, Sumba Island, Indonesia.
Article Synopsis
- The study assessed the effectiveness of two types of ivermectin in killing wild-caught Anopheles mosquitoes in cattle and buffalo on Sumba Island, Indonesia, finding cattle had higher blood levels of the drug.
- Nine species of Anopheles mosquitoes were tested for susceptibility to ivermectin, with varying degrees of lethality, revealing that long-lasting ivermectin outperformed the standard formulation, especially in cattle.
- Buffalo were found to attract mosquitoes more than cattle, horses, and humans, indicating they might need higher doses of long-lasting ivermectin to match the effectiveness seen in cattle, highlighting the potential of ivermectin as a livestock treatment for malaria control in Southeast Asia.
Is ivermectin surviving expectations in residual malaria control?
Lancet Infect Dis
November 2024
MIVEGEC Research Unit, Infectious Diseases and Vectors: Ecology, Genetics, Evolution, and Control, University of Montpellier, CNRS 5290, IRD 224, Institut de Recherche pour le Développement, Montpellier 34394, France; Department of Medical Zoology, Institut Pasteur de Dakar, Dakar, Senegal.
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