Vanadium-catalyzed Oxidative Conversion of Primary Aromatic Alcohols into Amides and Nitriles with Molecular Oxygen.

Amides or nitriles are important building blocks because of the widespread occurrence in chemistry and biology. The development of green and efficient catalytic approaches to introduce nitrogen functionality is highly desired. Herein, a vanadium-based material V-N-C-700 was prepared via a simple and convenient method and employed for liquid-phase catalytic ammoxidation of alcohols with molecular oxygen. By using V-N-C-700/2-picolinic acid, primary aromatic alcohols was smoothly converted into the amides and nitriles in the presence of urea. The corresponding aldehydes are the key intermediates, and 2-picolinic acid could significantly enhance oxidation of alcohols into aldehydes. The amides were formed simultaneously along with nitriles, rather than only from nitriles via successive hydration. This work further expands non-noble metal catalysts for the preparation of amides and nitriles.