This review aims to present an analysis and discussion on the processing of lignocellulosic biomass in terms of biorefinery concept and circular bioeconomy operating at high solids lignocellulosic (above 15% [w/w]) at the pretreatment, enzymatic hydrolysis stage, and fermentation strategy for an integrated lignocellulosic bioprocessing. Studies suggest high solids concentration enzymatic hydrolysis for improved sugars yields and methods to overcome mass transport constraints. Rheological and computational fluid dynamics models of high solids operation through evaluation of mass and momentum transfer limitations are presented. Also, the review paper explores operational feeding strategies to obtain high ethanol concentration and conversion yield, from the hydrothermal pretreatment and investigates the impact of mass load over the operational techniques. Finally, this review contains a brief overview of some of the operations that have successfully scaled up and implemented high-solids enzymatic hydrolysis in terms of the biorefinery concept.
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http://dx.doi.org/10.1016/j.biortech.2022.127044 | DOI Listing |
BMC Public Health
December 2024
Department of Chemistry, College of Natural and Computational Sciences, Wollega University, P.O. Box 395, Nekemte, Ethiopia.
Background: Indoor air pollution (IAP) is the major contributor (26%) to TB, in addition to other socioeconomic and environmental factors. It occurs in most developing countries like India, where people rely on the combustion of biomass-based solid fuels (low combustion efficiency and high pollution emissions) due to the prevailing socio-economic conditions. However, this cause-and-effect relationship between TB and IAP has not been studied much.
View Article and Find Full Text PDFSci Rep
December 2024
Nuclear Safeguards and Physical Protection Department, Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
The effective implementation of domestic and international safeguards necessitates verification techniques for Nuclear Materials (NM). Even in the case of very small quantities of NMs, accounting for and analyzing such traces can provide insights into the mass balance of NMs and/or state activities, ensuring consistency in state declarations. This paper proposes and benchmarks an absolute calibration methodology for estimating the uranium-mass content in large-volume barrels (200 L).
View Article and Find Full Text PDFIn Vivo
December 2024
Immunotherapy Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan;
Background/aim: Immune checkpoint blockade has achieved great success as a targeted immunotherapy for solid cancers. However, small molecules that inhibit programmed death 1/programmed death ligand 1 (PD-1/PD-L1) binding are still being developed and have several advantages, such as high bioavailability. Previously, we reported a novel PD-1/PD-L1-inhibiting small compound, SCL-1, which showed potent antitumor effects on PD-L1 tumors.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Food Engineering and Bioprocess Technology Program, Department of Food, Agriculture, and Bioresources, School of Environment, Resources, and Development, Asian Institute of Technology, Khlong Luang, Pathumthani 12120, Thailand. Electronic address:
This research investigates the impact of microwave power, processing time, and solid-to-solvent ratio on protein recovery from foxtail millet (Setaria italica), using an artificial neural network (ANN) and genetic algorithm (GA). The extracted protein and subsequent hydrolysates were also evaluated for their techno-functional, structural, and digestibility properties. The ANN model, trained with the Levenberg-Marquardt algorithm and optimized by a GA, identified optimal extraction conditions (960 W, 66.
View Article and Find Full Text PDFBiosens Bioelectron
December 2024
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China.
Conventional fluorescent probes with weak fluorescence signals and aggregation-caused quenching effect limits in biomarkers detection, thus requiring many labeled target molecules to combine their output to achieve higher signal-to noise. Here, we harness a "immune-sandwich" based affinity sensor with development of ultrabright aggregation-induced emission luminogens (AIEgens) microspheres as signal reporter. The fabricated sensor can simultaneously permit triple detection formats by naked eye, spectrum, and computer vision counting (termed "NeSCV sensor").
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