AI Article Synopsis
- A new chitosan-based hemostatic gauze has been developed, featuring a modified surface with a catechol compound to enhance bleeding control in critical situations.
- The gauze shows significantly improved performance in stopping bleeding in rat models, with blood loss reduced to less than 17% compared to standard chitosan gauze.
- It combines multiple functional effects – tissue anchoring, blood repelling, and fluid wicking – while being biodegradable and non-toxic, indicating a promising new mechanism for hemostatic treatment.
Article Abstract
Development of efficient hemostatic gauze is critical to increasing survival rate by quick bleeding control of life-threatening hemorrhage. Herein, a novel chitosan non-woven hemostatic gauze is made by slightly surface modification with a special catechol compound, i.e. 3-(9,11,13-pentadecatrienyl)-1,2-benzenediol with a long side hydrophobic alkyl chain. Its wettability, interaction with red blood cell and platelet, and hemostatic efficacy on rat injuries are evaluated. This chitosan-catechol gauze demonstrates impressive hemostatic performances on rat femoral artery and liver laceration injury models (blood loss of this modified chitosan gauze is less than 17% of that of pristine chitosan gauze). Additionally, it is biodegradable, and maintains non-cytotoxicity. It integrates three structure and function effects together, i.e., anchoring effect between catechol and tissue, blood repelling effect from hydrophobic alkyl chain, and blood wicking effect from hydrophilic chitosan. Therefore, a new hemostatic mechanism is proposed for the excellent hemostatic potentials of this chitosan gauze.
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| http://dx.doi.org/10.1016/j.carbpol.2022.119319 | DOI Listing |
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