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Takotsubo Cardiomyopathy: A Consequence of Blunt Chest Trauma.
Cureus
February 2025
Emergency Medicine, Duke Lifepoint Conemaugh Memorial Medical Center, Johnstown, USA.
Takotsubo cardiomyopathy (TTC), also known as stress-induced cardiomyopathy or "broken heart syndrome," is a transient form of myocardial dysfunction often triggered by emotional or physical stress. While typically associated with emotional distress and possible physical stress, TTC has rarely been reported in the context of physical trauma, including blunt chest injuries. This case report describes a novel instance of TTC in an 84-year-old woman who developed the condition following a motor vehicle accident, resulting in blunt chest trauma.
View Article and Find Full Text PDFUnique DUP-TRP/INV-DUP Structure Detected by Long-Read Sequencing.
Am J Med Genet A
March 2025
Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan.
Duplication-triplication/inverted-duplication (DUP-TRP/INV-DUP) is one of the mechanisms that causes genomic triplications. There are some characteristics of the DUP-TRP/INV-DUP; the appearance of a moving average of signal log2 ratio in genomic copy number analysis consisting of the highest center with lower steps on both sides; the chromosomal structure is composed of only two junctions; there are inverted repeats at the ends of the triplications and duplications on the same side and those connected in the opposite direction; and the size of the DUP-TRP/INV-DUP structure is generally less than the 1-Mb range. In this study, we analyzed two patients with DUP-TRP/INV-DUP involving PLP1 and MECP2.
View Article and Find Full Text PDFThe effects of isometric handgrip and post-exercise circulatory occlusion on muscle sympathetic nerve activity: A systematic review and meta-analysis.
Auton Neurosci
February 2025
Program for Pregnancy and Postpartum Health, Neurovascular Health Laboratory, Women and Children's Health Research Institute, Alberta Diabetes Institute, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada. Electronic address:
This systematic review and meta-analysis was conducted to identify a 'normative' sympathetic response to isometric handgrip and post-exercise circulatory occlusion. Structured searches of databases were performed until June 2024. We included all primary studies (other than systematic reviews and meta-analyses), and inclusion criteria were: population (all populations); intervention (isometric handgrip and post-exercise circulatory occlusion); comparator (baseline); and outcome (MSNA).
View Article and Find Full Text PDFFatal Seatbelt Syndrome in an Elderly Wheelchair User: A Case Report.
Cureus
March 2025
Department of Legal Medicine, Shiga University of Medical Science, Otsu, JPN.
Elderly wheelchair users face unique challenges in traffic collisions due to physiological fragility and the limitations of standard vehicle seatbelt systems. Seatbelt syndrome, a pattern of abdominal organ and spinal injuries, can be severe when seatbelts do not properly align with an individual's body configuration. Moreover, geriatric out-of-hospital cardiac arrest (OHCA) has a low survival rate, even with advanced prehospital care.
View Article and Find Full Text PDFLacerations rank as the most common paediatric injury that requires a physician evaluation. Glass is a frequent cause of such lacerations, however there is currently little to no information on this. Hence, this paper aims to describe the burden and characteristics of such injuries in Singapore.
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