In the last ten years, humanity has faced new challenges in the field of human and animal health, including emerging viral infections [...].
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| http://dx.doi.org/10.3390/microorganisms10030543 | DOI Listing |
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Induces Apoptosis in Chicken Oviduct Cells.
Vet Sci
December 2024
College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
(MS) is an important pathogen that can cause respiratory diseases in poultry and birds, leading to serious economic losses in the world and impacting the development of the poultry industry. However, the pathogenic mechanisms of MS infection are still unclear, resulting in a lack of effective diagnosis and treatment strategies. This study aimed to uncover the infection effect caused by MS in chicken oviduct cells.
View Article and Find Full Text PDFEvaluation of Fifteen 5,6-Dihydrotetrazolo[1,5-]quinazolines Against : Integrating In Vitro Studies, Molecular Docking, QSAR, and In Silico Toxicity Assessments.
J Fungi (Basel)
November 2024
Department of Biosciences and Biotechnologies, Graduate School of Bioresources and Bioenvironment Sciences, Kyushu University, 744 W5-674, Motooka Nishi-ku, Fukuoka 819-0395, Japan.
(), the second most prevalent Candida pathogen globally, has emerged as a major clinical threat due to its ability to develop high-level azole resistance. In this study, two new 5,6-dihydrotetrazolo[1,5-]quinazoline derivatives ( and ) were synthesized and characterized using IR, LC-MS, H, and C NMR spectra. Along with 13 previously reported analogues, these compounds underwent in vitro antifungal testing against clinical isolates using a serial dilution method (0.
View Article and Find Full Text PDFRoute Optimization for UVC Disinfection Robot Using Bio-Inspired Metaheuristic Techniques.
Biomimetics (Basel)
December 2024
Institute of Knowledge Technology, University Complutense of Madrid, 28040 Madrid, Spain.
The COVID-19 pandemic highlighted the urgent need for effective surface disinfection solutions, which has led to the use of mobile robots equipped with ultraviolet (UVC) lamps as a promising technology. This study aims to optimize the navigation of differential mobile robots equipped with UVC lamps to ensure maximum efficiency in disinfecting complex environments. Bio-inspired metaheuristic algorithms such as the gazelle optimization algorithm, whale optimization algorithm, bat optimization algorithm, and particle swarm optimization are applied.
View Article and Find Full Text PDFReplication Kinetics, Pathogenicity and Virus-induced Cellular Responses of Cattle-origin Influenza A(H5N1) isolates from Texas, United States.
Emerg Microbes Infect
December 2024
Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
The host range of HPAIV H5N1 was recently expanded to include ruminants, particularly dairy cattle in the United States (US). Shortly after, human H5N1 infection was reported in a dairy worker in Texas following exposure to infected cattle. Herein, we rescued the cattle-origin influenza A/bovine/Texas/24-029328-02/2024(H5N1, rHPbTX) and A/Texas/37/2024(H5N1, rHPhTX) viruses, identified in dairy cattle and human, respectively, and their low pathogenic forms, rLPbTX and rLPhTX, with monobasic HA cleavage sites.
View Article and Find Full Text PDFEvidence of an emerging triple-reassortant H3N3 avian influenza virus in China.
BMC Genomics
December 2024
The Key Lab of Animal Disease and Public Health / Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, Henan, 471023, China.
The H3 subtype of avian influenza virus (AIV) stands out as one of the most prevalent subtypes, posing a significant threat to public health. In this study, a novel triple-reassortant H3N3 AIV designated A/chicken/China/16/2023 (H3N3), was isolated from a sick chicken in northern China. The complete genome of the isolate was determined using next-generation sequencing, and the AIV-like particles were confirmed via transmission electron microscopy.
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