The fabrication of bespoke artificial defects on bearing raceways helps in mimicking incipient faults during real application or for directly validating the diagnostic technology depending on their shapes and sizes. This is particularly useful when run-to-failure experiments are time-consuming and even difficult in some cases. However, there has been limited systematic research on the design and fabrication of artificial defects on bearing raceways, particularly for the purpose of accelerated testing. In this work, micro-EDM is put forward as a potential technique for the fabrication of artificial defects using drilling/milling mode. A methodology is developed, not only to achieve the full control of the dimension and distribution of defects on a bearing element, but also to qualitatively and quantitatively perform the efficient characterization of the defect surface. A linear regression model with the inclusion of two-way interactions based on an analysis of variance (ANOVA) is presented to optimally select the process parameters. The verification experiments show that this mathematical model obtains a good fit for approximately 80% of the observed data. Through a combination of optical microscopy and confocal microscopy, the morphology and topography of the artificial defects was measured and compared. To conclude, micro-EDM evidences its great potential in terms of machining efficiency, e.g., with an MRR of 0.060 mm3/min, TWR of 0.032 mm3/min and dimensional controllability, e.g., the standard deviation of pitting diameter and depth being 0.5 µm and 0.8 µm, respectively, to achieve a desirable feature shape for bearing defects.
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http://dx.doi.org/10.3390/mi13030483 | DOI Listing |
Artif Organs
January 2025
Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
Background: Impairment of the visceral pleura following thoracic surgery often leads to air leaks and intrathoracic adhesions. For preventing such complications, mesothelial cell proliferation at the pleural defects can be effective. To develop new materials for pleural defects restoration, we constructed a hybrid artificial pleural tissue (H-APLT) combining polyglycolic acid (PGA) nanofiber sheets with a three-dimensional culture of mesothelial cells and fibroblasts and evaluated its therapeutic efficacy in a rat pleural defect model.
View Article and Find Full Text PDFNature
January 2025
Institut für Organische Chemie, Universität Würzburg, Würzburg, Germany.
Graphene is a single-layered sp-hybridized carbon allotrope, which is impermeable to all atomic entities other than hydrogen. The introduction of defects allows selective gas permeation; efforts have been made to control the size of these defects for higher selectivity. Permeation of entities other than gases, such as ions, is of fundamental scientific interest because of its potential application in desalination, detection and purification.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Obstetrics and Gynecology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
Prenatal sonographic diagnosis of congenital heart disease (CHD) can lead to improved morbidity and mortality. However, the diagnostic accuracy of ultrasound, the sole prenatal screening tool, remains limited. Failed prenatal or early newborn detection of cyanotic CHD (CCHD) can have disastrous consequences.
View Article and Find Full Text PDFJ Appl Oral Sci
January 2025
Universitas Airlangga, Faculty of Dental Medicine, Department of Oral Biology, Surabaya, East Java, Indonesia.
Unlabelled: Guided bone regeneration (GBR) is an alternative treatment for craniofacial bone defects reconstruction through membrane barrier adaptation, such as demineralized dentin material membrane (DDMM). DDMM is used as a substitute for GBR material, which aligns with Green Economy principles, it has a good biological osteoinductive and osteoconductive effects, and its structure resembles bones. The balance of bone remodeling when experiencing craniofacial defects will be altered and allow changes to resorption activity, so the mechanisms of osteoclastogenesis and bone resorption are vital.
View Article and Find Full Text PDFJ Cell Biol
March 2025
Department of Biological Sciences, Laboratory of Cell Biology and Biochemistry, Tokyo Metropolitan University, Tokyo, Japan.
The accumulation of defective polypeptides in cells is a major cause of various diseases. However, probing defective proteins is difficult because no currently available method can retrieve unstable defective translational products in a soluble state. To overcome this issue, there is a need for a molecular device specific to structurally defective polypeptides.
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