Ubiquitin modification controls protein stability and cargo trafficking, and in this issue Duncan et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202107114) reveal a unique mechanism through which Rab40b/Cul5-mediated ubiquitylation of Rap2 regulates its activity and recycling to the leading edge to control cell migration and invasion.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961291 | PMC |
| http://dx.doi.org/10.1083/jcb.202203029 | DOI Listing |
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