Homocysteine levels can be impacted by enzymes variations. To correlate , and variants with homocysteine levels in the blood and follicular fluid and assisted reproduction results. (rs2274976, rs1801131, rs1801133), (rs1805087) and (rs1801394) genotyping was performed by TaqMan assays and compared with homocysteine levels, measured by ELISA, to oocytes retrieved and to the pregnancy status of women with endometriosis and controls. The G allele and GG genotype were more common in patients with endometriosis. They also showed lower levels of homocysteine and more clinical gestations. Epistasis analysis showed a model associated with gestational results, composed of variants (CC+AG). The summation effect of variants in genes participating in folate metabolism was associated with pregnancy status in Brazilian women. variants were more observed in endometriosis patients, as well as lower follicular Hcy levels and increased clinical pregnancy results.
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